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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MATERNAL PLASMA HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 RNA LEVEL - A DETERMINANT AND PROJECTED THRESHOLD FOR MOTHER-TO-CHILD TRANSMISSION
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MATERNAL PLASMA HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 RNA LEVEL - A DETERMINANT AND PROJECTED THRESHOLD FOR MOTHER-TO-CHILD TRANSMISSION

机译：血浆人免疫功能低下病毒1型RNA水平-母婴传播的决定因素和预计阈值

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摘要

To prevent mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission, it is important to identify its determinants, Because HIV-1 RNA levels can be reduced by antiviral therapy, we examined the role of maternal plasma HIV-1 RNA level in mother-to-child transmission, We used quantitative competitive PCR to measure HIV-1 RNA in 30 infected pregnant women and then followed their infants prospectively; 27% of the women transmitted HIV-1 to their infants and maternal plasma HIV-1 RNA level correlated strikingly with transmission. Eight of the 10 women with the highest HIV-1 RNA levels at delivery (190,400-1,664,100 copies per mi of plasma) transmitted, while none of the 20 women with lower levels (500-155,800 copies per mi) did (P = 0.0002), Statistical analysis of the distribution of HIV-1 RNA loads in these 30 women projected a threshold for mother-to-child transmission in a larger population; the probability of a woman with a viral RNA level of less than or equal to 100,000 copies per mi not transmitting is predicted to be 97%. Examination of serial HIV-1 RNA levels during pregnancy showed that viral load was stable in women who did not initiate or change antiviral therapy. These data identify maternal plasma HIV-1 RNA level as a major determinant of mother-to-child transmission and suggest that quantitation of HIV-1 RNA may predict the risk of transmission.
机译：为了防止1型母婴人类免疫缺陷病毒（HIV-1）传播，重要的是要确定其决定因素，因为抗病毒疗法可以降低HIV-1 RNA的水平，所以我们研究了母体血浆HIV-1的作用母婴传播中的RNA水平，我们使用定量竞争PCR来测量30名受感染孕妇中的HIV-1 RNA，然后对其婴儿进行前瞻性研究。 27％的妇女将HIV-1传播给婴儿，母亲血浆HIV-1 RNA水平与传播显着相关。在分娩时HIV-1 RNA水平最高的10名妇女中有8名（血浆每英里190,400-1,664,100拷贝）传播，而在水平较低的20名妇女中（500-155,800拷贝每英里）没有传播（P = 0.0002） ，对这30名妇女中HIV-1 RNA含量分布的统计分析预测，在更大的人群中母婴传播的阈值；病毒RNA水平小于或等于100,000拷贝/ mi的女性不传播的可能性预计为97％。怀孕期间对系列HIV-1 RNA水平的检查表明，未开始或未改变抗病毒治疗的女性病毒载量稳定。这些数据确定了母体血浆HIV-1 RNA水平是母婴传播的主要决定因素，并表明对HIV-1 RNA的定量可以预测传播的风险。

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