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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Major histocompatibility complex class Ⅱ DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups
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Major histocompatibility complex class Ⅱ DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups

机译：主要组织相容性复杂的Ⅱ类DR等位基因DRB1 * 1501和编码HLA-DR13的等位基因与不同种族的孕产妇传播的人类免疫缺陷病毒1感染的减少有关

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摘要

Transmission of human immunodeficiency virus 1 (HIV-1) from an infected women to her offspring during gestation and delivery was found to be influenced by the infant's major histocompatibility complex class Ⅱ DRB1 alleles. Forty-six HIV-infected infants and 63 seroreverting infants, born with passively acquired anti-HIV antibodies but not becoming detectably infected, were typed by an automated nucleotide-sequence-based technique that uses low-resolution PCR to select either the simpler Taq or the more demanding T7 sequencing chemistry. One or more DR13 alleles, including DRB1*1301, 1302, and 1303, were found in 31.7% of seroreverting infants and 15.2% of those becoming HIV-infected [OR (odds ratio) = 2.6 (95% confidence interval 1.0-6.8); P = 0.048]. This association was influenced by ethnicity, being seen more strongly among the 80 Black and Hispanic children [OR = 4.3 (1.2-16.4); P = 0.023], with the most pronounced effect among Black infants where 7 of 24 seroreverters inherited these alleles with none among 12 HIV-infected infants (Haldane OR = 12.3; P = 0.037). The previously recognized association of DR13 alleles with some situations of long-term nonprogression of HIV suggests that similar mechanisms may regulate both the occurrence of infection and disease progression after infection. Upon examining for residual associations, only the DR2 allele DRB1*1501 was associated with seror-eversion in Caucasoid infants (OR = 24; P = 0.004). Among Caucasoids the DRB1*03011 allele was positively associated with the occurrence of HIV infection (P = 0.03).
机译：发现人类免疫缺陷病毒1（HIV-1）在妊娠和分娩过程中从受感染妇女向其后代的传播受婴儿主要组织相容性复合物II类DRB1等位基因的影响。通过自动基于核苷酸序列的技术对46例被HIV感染的婴儿和63例通过自身获得的抗HIV抗体出生但没有被检测到感染的Seroreverting婴儿，进行自动核苷酸序列技术的分型，该技术使用低分辨率PCR选择较简单的Taq或对T7测序化学的要求更高。在31.7％的抗血清婴儿和15.2％的HIV感染婴儿中发现了一个或多个DR13等位基因，包括DRB1 * 1301、1302和1303 [OR（优势比）= 2.6（95％置信区间1.0-6.8）。 ; P = 0.048]。这种联系受种族的影响，在80名黑人和西班牙裔儿童中更为明显[OR = 4.3（1.2-16.4）； P = 0.023]，在黑人婴儿中效果最为明显，其中24个变逆者中有7个继承了这些等位基因，而在12个HIV感染的婴儿中却没有这些等位基因（Haldane OR = 12.3； P = 0.037）。先前公认的DR13等位基因与HIV长期未进展的某些情况之间的关联表明，相似的机制可能会调节感染的发生和感染后疾病的进展。在检查残留关联后，仅DR2等位基因DRB1 * 1501与高加索婴儿的血清外翻相关（OR = 24； P = 0.004）。在高加索人中，DRB1 * 03011等位基因与HIV感染的发生呈正相关（P = 0.03）。

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