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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >OVULATION EFFICIENCY IS REDUCED IN MICE THAT LACK PLASMINOGEN ACTIVATOR GENE FUNCTION - FUNCTIONAL REDUNDANCY AMONG PHYSIOLOGICAL PLASMINOGEN ACTIVATORS
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OVULATION EFFICIENCY IS REDUCED IN MICE THAT LACK PLASMINOGEN ACTIVATOR GENE FUNCTION - FUNCTIONAL REDUNDANCY AMONG PHYSIOLOGICAL PLASMINOGEN ACTIVATORS

机译：缺乏纤溶酶原激活物基因功能的小鼠的排卵效率降低-生理纤溶酶原激活物之间的功能冗余

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Several lines of indirect evidence suggest that plasminogen activation plays a crucial role in degradation of the follicular wall during ovulation. However, single-deficient mice lacking tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), or PA inhibitor type 1 (PAI-1) gene function were recently found to have normal reproduction, although mice with a combined deficiency of tPA and uPA were significantly less fertile. To investigate whether the reduced fertility of mice lacking PA gene function is due to a reduced ovulation mechanism, we have determined the ovulation efficiency in 25-day-old mice during gonadotropin-induced ovulation. Our results reveal that ovulation efficiency is normal in mice with a single deficiency of tPA or uPA but reduced by 26% in mice lacking both physiological PAs. This result suggests that plasminogen activation plays a role in ovulatory response, although neither tPA nor uPA individually or in combination is obligatory for ovulation. The loss of an individual PA seems to be Functionally complemented by the remaining PA but this compensation does not appear to involve any compensatory up-regulation. Our data imply that a functionally redundant mechanism for plasmin formation operates during gonadotropin-induced ovulation and that PAs together with other proteases generate the proteolytic activity required for follicular wall degradation.
机译：间接证据表明，纤溶酶原的激活在排卵过程中对卵泡壁的降解起着至关重要的作用。但是，最近发现缺乏组织型纤溶酶原激活物（tPA），尿激酶型纤溶酶原激活物（uPA）或PA抑制剂1型（PAI-1）基因功能的单缺陷小鼠具有正常的繁殖能力，尽管具有缺乏tPA和uPA的受精能力明显较差。要研究缺乏PA基因功能的小鼠的生育力降低是否是由于排卵机理的降低，我们已经确定了促性腺激素诱导排卵期间25日龄小鼠的排卵效率。我们的结果表明，排卵效率在tPA或uPA单一缺陷的小鼠中是正常的，但在缺乏两种生理PA的小鼠中排卵效率却降低了26％。该结果表明纤溶酶原激活在排卵反应中起作用，尽管单独或组合使用tPA和uPA都不是排卵所必需的。单个PA的丢失似乎在功能上由剩余的PA进行了补充，但是这种补偿似乎不涉及任何补偿性上调。我们的数据表明，在促性腺激素诱导的排卵过程中，发生纤溶酶形成的功能冗余机制起作用，并且PA与其他蛋白酶一起产生卵泡壁降解所需的蛋白水解活性。

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