INHIBITION OF A PLANT VIRUS INFECTION BY ANALOGS OF MELITTIN

Marcos JF; Beachy RN; Houghten RA; Blondelle SE; Perezpaya E

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INHIBITION OF A PLANT VIRUS INFECTION BY ANALOGS OF MELITTIN

机译：蜂毒肽类似物抑制植物病毒感染

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摘要

An approach that enables identification of specific synthetic peptide inhibitors of plant viral infection is reported. Synthetic analogs of melittin that have sequence and structural similarities to an essential domain of tobacco mosaic virus coat protein were found to possess highly specific antiviral activity. This approach involves modification of residues located at positions analogous to those that are critical for virus assembly. The degree of inhibition found correlates well with sequence similarities between the viral capsid protein and the melittin analogs studied as well as with the induced conformational changes that result upon interaction of the peptides and ribonucleic acid.

机译：报道了一种能够鉴定植物病毒感染的特定合成肽抑制剂的方法。已发现与烟草花叶病毒外壳蛋白的必需域具有序列和结构相似性的蜂毒肽合成类似物具有高度特异性的抗病毒活性。该方法涉及修饰位于类似于病毒组装关键位置的残基。发现的抑制程度与病毒衣壳蛋白和蜂毒肽类似物之间的序列相似性以及由于肽和核糖核酸相互作用导致的诱导的构象变化密切相关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第26期|p.12466-12469|共4页
作者
Marcos JF; Beachy RN; Houghten RA; Blondelle SE; Perezpaya E;
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作者单位

Marcos JF, SCRIPPS CLIN & RES INST, 10666 N TORREY PINES RD, LA JOLLA, CA 92037, USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Antiviral; Tobacco mosaic virus.; Tobacco mosaic virus; Nucleotide sequence; Cowpea strain; Peptides.; Resistance; Acids; Rna;

机译：抗病毒;烟草花叶病毒;烟草花叶病毒;核苷酸序列;牛豌豆菌株;肽;抗性;酸;Rna;

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6. Inhibition of a plant virus infection by analogs of melittin. [O] . J F Marcos, R N Beachy, R A Houghten, 1995

机译：蜂毒类似物对植物病毒感染的抑制作用。
7. Inhibition of a plant virus infection by analogs of melittin. [O] . Marcos, J F, Beachy, R N, Houghten, R A, 1995

机译：蜂毒类似物对植物病毒感染的抑制作用。

INHIBITION OF A PLANT VIRUS INFECTION BY ANALOGS OF MELITTIN

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