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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Analysis of naive lung CD4 T cells provides evidence of functional lung to lymph node migration
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Analysis of naive lung CD4 T cells provides evidence of functional lung to lymph node migration

机译:幼稚肺CD4 T细胞的分析提供了功能性肺向淋巴结迁移的证据

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摘要

The proportion of CD4 T cells with phenotypic and functional properties of naive cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphin-gosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of ~14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin prevents entry of naieve CD4 T cells into the lung. Based on treatment with anti-CD62L and the use of CCR7~(-/-) cells, lung naive CD4 T cells appear to migrate to the mediastinal lymph nodes along a CD62L-inde-pendent, CCR7-dependent pathway. Cells that have entered the node in this manner are competent to respond to antigen. Thus, a portion (approximately one-half) of naive CD4 T cells appears to enter the mediastinal lymph nodes through a blood-to-fung-to-lymph node route.
机译:在肺实质和淋巴结中,具有幼稚细胞表型和功能特性的CD4 T细胞在总CD4 T细胞中所占的比例相似。用Sphin-gosine-1-磷酸激动剂治疗后,这些细胞的频率急剧下降,但与血液CD4 T细胞相比,延迟了约14小时。抗CD62L和百日咳毒素都不能阻止幼稚的CD4 T细胞进入肺。基于抗CD62L的治疗和CCR7〜(-/-)细胞的使用,幼稚的CD4 T细胞似乎沿着CD62L独立的CCR7依赖性途径迁移至纵隔淋巴结。以这种方式进入节点的细胞能够对抗原作出反应。因此,幼稚的CD4 T细胞的一部分(大约一半)似乎是通过血液-真菌-淋巴结途径进入纵隔淋巴结的。

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