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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
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Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus

机译：Wolbachia菌株wMel诱导白纹伊蚊的细胞质不相容并阻止登革热传播

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摘要

Wolbachia inherited bacteria are able to invade insect populations using cytoplasmic incompatibility and provide new strategies for controlling mosquito-borne tropical diseases, such as dengue. The overreplicating wMelPop strain was recently shown to strongly inhibit the replication of dengue virus when introduced into Aedes aegypti mosquitoes, as well as to stimulate chronic immune up-regulation. Here we show that stable introduction of the wMel strain of Drosophila melanogaster into Aedes albopictus, a vector of dengue and other arboviruses, abolished the transmission capacity of dengue virus-challenged mosquitoes. Immune up-regula-tion was observed in the transinfected line, but at a much lower level than that previously found for transinfected Ae. aegypti. Transient infection experiments suggest that this difference is related to Ae. albopictus immunotolerance of Wolbachia, rather than to the Wolbachia strain used. This study provides an example of strong pathogen inhibition in a naturally Wo/bach/a-infected mosquito species, demonstrating that this inhibition is not limited to naturally naive species, and suggests that the Wolbachia strain is more important than host background for viral inhibition. Complete bidirectional cytoplasmic incompatibility was observed with WT strains infected with the naturally occurring Ae. albopictus Wolbachia, and this provides a mechanism for introducing ivMel into natural populations of this species.
机译：Wolbachia遗传细菌能够利用细胞质不相容性入侵昆虫种群，并提供了控制蚊子传播的热带疾病（如登革热）的新策略。最近显示，过度复制的wMelPop菌株在引入埃及伊蚊后会强烈抑制登革热病毒的复制，并刺激慢性免疫上调。在这里，我们表明，果蝇wMel菌株稳定地引入白纹伊蚊，登革热和其他虫媒病毒的载体，消除了登革热病毒感染的蚊子的传播能力。在转染品系中观察到了免疫上调，但其水平比先前发现的转染Ae更低。埃及。瞬时感染实验表明，这种差异与Ae有关。 Wolbachia的白蛋白免疫耐受性，而不是所用的Wolbachia菌株。这项研究提供了在自然感染Wo / bach / a的蚊子中强烈抑制病原菌的一个例子，证明了这种抑制作用不仅限于天然幼虫，并且表明Wolbachia菌株比宿主背景对病毒的抑制作用更重要。用感染了天然Ae的野生型菌株观察到完全的双向胞质不相容性。 Wolbachia，这提供了将ivMel引入该物种自然种群的机制。

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    Marcus S. C. Blagrove; Camilo Arias-Goeta; Anna-Bella Failloux; Steven P. Sinkins;

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    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom and 75724 Paris Cedex 15, France;

    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France;

    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France;

    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom and 75724 Paris Cedex 15, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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