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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mechanical stress triggers cancer cell migration
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Mechanical stress triggers cancer cell migration

机译：机械应力触发癌细胞迁移

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摘要

Cancer cells experience compressive stress as they undergo uncontrolled proliferation in the body's confined spaces. To determine how these stresses affect tumor cells, Janet Tse et al. (pp. 911-916) subjected mammary epithelial cells to mechanical compression by pressing them against a membrane surface with a weighted piston. The authors found that compressive stress enhanced the migration of mammary carcinoma cells by stimulating the formation of "leader cells" at the leading edge of cell sheets. Leader cells extend protrusions in the direction of migration while maintaining connections with trailing follower cells. Compression also induced cells to secrete a protein called fibronectin that improves migration and leader cell formation by increasing the adhesion between cells and the surface.
机译：癌细胞会在身体的狭窄空间内不受控制地增殖，因此会承受压迫性压力。为了确定这些压力如何影响肿瘤细胞，珍妮特谢等人。 （第911-916页）（第911-916页）用加重的活塞将乳腺上皮细胞压向膜表面，使其受到机械压缩。作者发现，压应力通过刺激细胞片前沿的“前导细胞”的形成而增强了乳腺癌细胞的迁移。前导细胞在迁移方向上延伸突起，同时保持与尾随的跟随细胞的连接。压缩还诱导细胞分泌称为纤连蛋白的蛋白，该蛋白通过增加细胞与表面之间的粘附力来改善迁移和引导细胞的形成。

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