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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CD4 and CD8 T cells require different membrane gangliosides for activation
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CD4 and CD8 T cells require different membrane gangliosides for activation

机译：CD4和CD8 T细胞需要不同的膜神经节苷脂才能激活

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摘要

T cells compose a crucial part of the immune system and require activation. The first step of T cell activation requires the movement of one of their surface molecules, known as the receptor, into cell-membrane regions known as lipid rafts. Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation has not been established. Here, we show that different types of T cells require different and distinct ganglioside types for activation. We also describe a role for gangliosides in asthma, a disorder involving the immune system.
机译：T细胞构成免疫系统的关键部分，需要激活。 T细胞活化的第一步需要将其一个表面分子（称为受体）移动到称为脂筏的细胞膜区域。已知称为神经节苷脂的分子是脂质筏的主要成分，但尚未确定它们在T细胞活化中的作用。在这里，我们表明不同类型的T细胞需要不同和不同的神经节苷脂类型进行激活。我们还描述了神经节苷脂在哮喘（一种涉及免疫系统的疾病）中的作用。

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    Masakazu Nagafuku; Kaori Okuyama; Yuri Onimaru; Akemi Suzuki; Yuta Odagiri; Tadashi Yamashita; Katsunori lwasaki; Michihiro Fujiwara; Motoaki Takayanagi; Isao Ohno; Jin-ichi lnokuchi;

  • 作者单位

    Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Sendai 981-8558, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan;

    Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan;

    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan;

    Institute of Glycoscience, Tokai University, Kanagawa 259-1292, Japan;

    Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Sendai 981-8558, Japan;

    Division of Integrated Life Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan;

    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan Academic, Industrial and Governmental Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka 814-0180, Japan;

    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan;

    Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan;

    Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Sendai 981-8558, Japan;

    Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Sendai 981-8558, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan Academic, Industrial and Governmental Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka 814-0180, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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