Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

Pengpeng Ma; Hua Pan; Rusty L. Montgomery; Eric N. Olson; Richard M. Schultz

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Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

机译：组蛋白脱乙酰基酶1（HDAC1）和HDAC2的补偿功能调节小鼠卵母细胞发育过程中的转录和凋亡

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Oogenesis-the development of an egg, or oocyte, capable of being fertilized-is accompanied by dramatic changes in the activity, or expression, of various genes. However, oogenesis also requires the termination of transcription-the reading of DNA to produce mRNA, an intermediate step in the production of proteins from genes (1). This transcriptional quiescence involves changes called histone posttranslational modifications, but the role of these changes is poorly understood. We report that oocytes deficient in specific enzymes that catalyze histone posttranslational modifications are infertile because of changes in gene expression as well as activation of apoptosis (i.e., cell death).

机译：卵子发生-能够受精的卵或卵母细胞的发育-伴随着各种基因的活性或表达的急剧变化。然而，卵子发生还需要终止转录-DNA的读取以产生mRNA，这是从基因产生蛋白质的中间步骤（1）。这种转录的静止涉及称为组蛋白翻译后修饰的变化，但人们对这些变化的作用了解甚少。我们报道，由于基因表达的变化以及凋亡的激活（即细胞死亡）的改变，缺乏能催化组蛋白翻译后修饰的特定酶的卵母细胞是不育的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第8期|p.2704|共1页
作者
Pengpeng Ma; Hua Pan; Rusty L. Montgomery; Eric N. Olson; Richard M. Schultz;
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作者单位

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104;

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104;

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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专利

1. Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse [J] . Pengpeng Ma, Richard M. Schultz PLoS Genetics . 2013,第3期

机译：组蛋白脱乙酰基酶2（HDAC2）通过小鼠卵母细胞成熟过程中的H4K16脱乙酰基调节染色体的分离和线粒体功能
2. Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. [J] . Ma P, Schultz RM Developmental biology . 2008,第1期

机译：组蛋白脱乙酰基酶1（HDAC1）调节组蛋白乙酰化，发育和植入前小鼠胚胎中的基因表达。
3. Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos [J] . Pengpeng Ma, Richard M. Schultz Developmental biology . 2008,第1期

机译：组蛋白脱乙酰基酶1（HDAC1）调节组蛋白乙酰化，发育和植入前小鼠胚胎中的基因表达。
4. Dynamic Phosphorylation Regulates Histone Deacetylase Localization, Interactions, and Cell Cycle-dependent Functions [C] . Amanda J. Guise, Rommel A. Mathias, Todd M. Greco, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：动态磷酸化调节组蛋白脱乙酰酶定位，相互作用和细胞周期依赖性功能
5. Regulation of NF-kappaB activity by the class I histone deacetylases, HDAC1, HDAC2, HDAC3 corepressors and the spermidine/spermine N1 acetyltransferase 2 (SSAT2) coactivator. [D] . Boeke, Marta. 2008

机译：I类组蛋白脱乙酰基酶，HDAC1，HDAC2，HDAC3核心加压因子和亚精胺/精胺N1乙酰转移酶2（SSAT2）共激活剂对NF-κB活性的调节。
6. PNAS Plus: Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development [O] . Pengpeng Ma, Hua Pan, Rusty L. Montgomery, 2012

机译：PNAS Plus：组蛋白脱乙酰基酶1（HDAC1）和HDAC2的补偿功能调节小鼠卵母细胞发育过程中的转录和凋亡
7. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development [O] . P. Ma, H. Pan, R. L. Montgomery, 2012

机译：组蛋白脱乙酰酶1（HDAC1）和HDAC2在小鼠卵母细胞发育过程中调节转录和细胞凋亡的补偿功能

Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

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