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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Altered antisense-to-sense transcript ratios in breast cancer
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Altered antisense-to-sense transcript ratios in breast cancer

机译：乳腺癌反义转录物比率的改变

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摘要

Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense transcripts likely represent long ncRNAs. A subset of genes that mainly generate antisense transcripts in normal but not cancer cells is involved in essential metabolic processes. These findings suggest fundamental differences in global RNA regulation between normal and cancer cells that might play a role in tumorigenesis.
机译：转录组分析研究表明，转录了很大一部分基因组，许多转录本的功能独立于其蛋白质编码潜力。非编码RNA（ncRNA）在正常的生理过程和肿瘤发生中的相关性越来越得到认可。在这里，我们描述了正常和赘生性乳腺组织之间有义和反义转录本分布的一致和显着差异。许多差异表达的反义转录物可能代表长的ncRNA。主要在正常细胞而非癌细胞中产生反义转录物的基因的子集参与基本的代谢过程。这些发现表明正常细胞与癌细胞之间在全局RNA调节方面的根本差异可能在肿瘤发生中起作用。

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    Reo Maruyama; Michail Shipitsin; Sibgat Choudhury; Zhenhua Wu; Alexei Protopopov; Jun Yao; Pang-Kuo Lo; Marina Bessarabova; Alex Ishkin; Yuri Nikolsky; X. Shirley Liu; Saraswati Sukumar; Kornelia Polyak;

  • 作者单位

    Departments of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115,Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115,Department of Medicine, Harvard Medical School, Boston, MA 02115;

    Departments of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115,Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115,Department of Medicine, Harvard Medical School, Boston, MA 02115;

    Departments of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115,Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115,Department of Medicine, Harvard Medical School, Boston, MA 02115;

    Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115,Harvard School of Public Health, Boston, MA 02115;

    Departments of Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115;

    Department of Neuro-Oncology, M.D. Anderson Cancer Center, Houston, TX 77030;

    Johns Hopkins Oncology Center, Baltimore, MD 21231;

    Vaviiov Institute for General Genetics, Russian Academy of Sciences, Moscow 119331, Russia;

    Vaviiov Institute for General Genetics, Russian Academy of Sciences, Moscow 119331, Russia;

    GeneGo, Inc., St. Joseph, Ml 49085;

    Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115,Harvard School of Public Health, Boston, MA 02115;

    Johns Hopkins Oncology Center, Baltimore, MD 21231;

    Departments of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115,Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115,Department of Medicine, Harvard Medical School, Boston, MA 02115,Harvard Stem Cell Institute, Cambridge, MA 02138;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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