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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors
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Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors

机译：前额叶皮质锥体神经元的兴奋性通过细胞内2型大麻素受体的激活来调节

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摘要

The endocannabinoid (eCB) system is widely expressed throughout the central nervous system (CNS) and the functionality of type-1 cannabinoid receptors in neurons is well documented. In contrast, there is little knowledge about type-2 cannabinoid receptors (CB_2Rs) in the CNS. Here, we show that CB_2Rs are located intracellularly in layer Ⅱ/Ⅲ pyramidal cells of the rodent medial prefrontal cortex (mPFC) and that their activation results in IP_3R-dependent opening of Ca~(2+)-activated Cl channels. To investigate the functional role of CB_2R activation, we induced neuronal firing and observed a CB_2R-mediated reduction in firing frequency. The description of this unique CB_2R-mediated signaling pathway, controlling neuronal excitability, broadens our knowledge of the influence of the eCB system on brain function.
机译：内源性大麻素（eCB）系统在整个中枢神经系统（CNS）中广泛表达，并且神经元中1型大麻素受体的功能已得到充分证明。相反，对CNS中的2型大麻素受体（CB_2Rs）知之甚少。在这里，我们表明CB_2Rs位于啮齿动物内侧前额叶皮层（mPFC）的第Ⅱ/Ⅲ层锥体细胞内，并且它们的激活导致Ca〜（2+）激活的Cl通道的IP_3R依赖性开放。要研究CB_2R激活的功能作用，我们诱导了神经元放电，并观察到CB_2R介导的放电频率降低。这种独特的CB_2R介导的信号通路控制神经元兴奋性的描述，拓宽了我们对eCB系统对脑功能的影响的认识。

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    Femke S. den Boon; Pascal Chameau; Qiluan Schaafsma-Zhao; Willem van Aken; Monica Bari; Sergio Oddi; Chris G. Kruse; Mauro Maccarrone; Wytse J. Wadman; Taco R. Werkman;

  • 作者单位

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

    Department of Experimental Medicine and Biochemical Sciences, Tor Vergata University, 00133 Rome, Italy,European Center for Brain Research/Santa Lucia Foundation, 00179 Rome, Italy;

    European Center for Brain Research/Santa Lucia Foundation, 00179 Rome, Italy,Department of Biorhedical Sciences, University of Teramo, 64100 Teramo, Italy;

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

    European Center for Brain Research/Santa Lucia Foundation, 00179 Rome, Italy,Department of Biorhedical Sciences, University of Teramo, 64100 Teramo, Italy;

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    calcium-activated chloride current; firing rate; whole-cell current voltage clamp; intracellular calcium stores;

    机译：钙激活的氯化物电流;燃烧率;全电池电流电压钳;细胞内钙存储;

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