Potential drug for ischemic stroke

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Potential drug for ischemic stroke

机译：缺血性中风的潜在药物

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Researchers have long known that blocking the activity of a scaffolding protein called PSD-95 in the junctions between nerve cells might lead to a potential treatment for stroke. A dearth of candidate drugs targeting PSD-95 with reasonably high affinity prompted Anders Bach et al. (pp. 3317-3322) to synthesize a dimeric molecule called Tat-N-dimer, which inhibits PSD-95 by binding to a canonical motif in the protein with unprecedentedaffinity.

机译：研究人员早就知道，在神经细胞之间的连接处阻断称为PSD-95的脚手架蛋白的活性可能会导致中风的潜在治疗。缺乏以合理高亲和力靶向PSD-95的候选药物促使了Anders Bach等人。（第3317-3322页）合成称为Tat-N-二聚体的二聚体分子，该分子通过以前所未有的亲和力与蛋白质中的规范基序结合来抑制PSD-95。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第9期|p.3192|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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机译：神经重症监护病房的急性缺血性中风患者的潜在药物相互作用
2. Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design [J] . Yeatts Sharon D., Broderick Joseph P., Chatterjee Anjan, International journal of stroke: official journal of the International Stroke Society . 2018,第6期

机译：Elteplase用于治疗急性缺血性卒中患者低国家卫生冲程规模，而不是明确禁用缺陷（患有轻度症状棱镜的缺血性卒中的潜力）：理由和设计
3. Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke [J] . YanB.C., ParkJ.H., AhnJ.H., Journal of Neuroscience Research . 2014,第6期

机译：利培酮（一种非典型抗精神病药）对缺血性中风的大鼠和沙鼠模型的后处理的神经保护以及在缺血性中风的沙鼠模型中抗氧化剂的维持
4. The Determining Factors in Prescribing Anti-Hypertensive Drugs to First-Ever Ischemic Stroke Patients [C] . Rasvini Rajendran, Zaitul Marlizawati Zainuddin International Conference on Industrial Engineering, Management Science and Application . 2016

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5. The role of iron-induced oxidative stress in acute ischemic stroke and the potential role for fasciculations in their therapy. [D] . Mehta, Shyamal H. 2003

机译：铁诱导的氧化应激在急性缺血性卒中中的作用以及絮凝剂在其治疗中的潜在作用。
6. Potential Drug-drug Interactions in Acute Ischemic Stroke Patients at the Neurological Intensive Care Unit [O] . Dejan Z. Aleksic, Slobodan M. Jankovic, Milos N. Mlosavljevic, 2019

机译：神经重症监护病房的急性缺血性卒中患者的潜在药物相互作用
7. Potential drug-drug interactions in acute ischemic stroke patients at the Neurological Intensive Care Unit [O] . Dejan Z. Aleksic, Slobodan M. Jankovic, Milos N. Mlosavljevic, 2019

机译：急性缺血性脑卒中患者在神经精密护理单位中的潜在药物 - 药物相互作用

Potential drug for ischemic stroke

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