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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
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Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum

机译：童年时期的虐待与海马区CA3，齿状回和下丘脑容积减少有关

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摘要

Hippocampal vulnerability to the ravages of stress is one of the key translational neuroscience discoveries of the 20th century (1). Several studies have since reported smaller hippocampal size in a host of psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (2). More recently, attention has been focused on the effects of childhood abuse, because consistent reports have emerged of diminished hippocampal volume in adults with maltreatment histories and maltreatment is a risk factor for all the psychiatric disorders associated with reduced hippocampal size. Hence, exposure to severe psychosocial stress during childhood may serve as a unifying mechanism.
机译：海马对应激的脆弱性是20世纪转化神经科学的重要发现之一（1）。此后有几项研究报告了在许多精神疾病中，包括重度抑郁症和创伤后应激障碍（2），海马体较小。最近，注意力已集中在儿童期虐待的影响上，因为不断有报道表明，有虐待历史的成年人海马体积减小，而虐待是所有与海马体型减少有关的精神疾病的危险因素。因此，在儿童时期暴露于严重的社会心理压力可能是一种统一的机制。

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    Martin H. Teicher; Carl M. Anderson; Ann Polcari;

  • 作者单位

    Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478,Department of Psychiatry, Harvard Medical School, Boston, MA 02115;

    Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478,Department of Psychiatry, Harvard Medical School, Boston, MA 02115,Brain Imaging Center, McLean Hospital, Belmont, MA 02478;

    Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478,Department of Psychiatry, Harvard Medical School, Boston, MA 02115,School of Nursing, Northeastern University, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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