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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Full regeneration of the tribasal Polypterus fin
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Full regeneration of the tribasal Polypterus fin

机译：三基息肉鳍的完全再生

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摘要

Full limb regeneration is a property that seems to be restricted to urodele amphibians. Here we found that Polypterus. the most basal living ray-finned fish, regenerates its pectoral lobed fins with a remarkable accuracy. Pectoral Polypterus fins are complex, formed by a well-organized endoskeleton to which the exoskeieton rays are connected. Regeneration initiates with the formation of a blastema similar to that observed in regenerating amphibian limbs. Retinoic acid induces dose-dependent phenotypes ranging from inhibition of regeneration to apparent anterior-posterior duplications. As in all developing tetrapod limbs and regenerating amphibian blastema. Sonic hedgehog is expressed in the posterior mesenchyme during fin regeneration. Hedgehog signaling plays a role in the regeneration and patterning processes: an increase or reduction of fin bony elements results when this signaling is activated or disrupted, respectively. The tail fin also regenerates but, in contrast with pectoral fins, regeneration can resume after release from the arrest caused by hedgehog inhibition. A comparative analysis of fin phenotypes obtained after retinoic acid treatment or altering the hedgehog signaling levels during regeneration allowed us to assign a limb tetrapod equivalent segment to Polypterus fin skeletal structures, thus providing clues to the origin of the autopod. We propose that appendage regeneration was a common property of vertebrates during the fin to limb transition.
机译：全肢再生是一种似乎仅限于urodele两栖动物的特性。在这里，我们发现了息肉。最基础的活鳍鱼，以极高的精确度繁殖其胸鳍。胸鳍鳍很复杂，由组织良好的内骨骼形成，外骨骼射线与之相连。再生开始时形成的胚细胞类似于再生两栖动物肢体中所观察到的胚细胞。维甲酸诱导剂量依赖性表型，从抑制再生到明显的前后重复。像所有发育中的四足动物四肢和再生两栖母细胞一样。声波刺猬在鳍再生期间在后间质中表达。刺猬信号在再生和构图过程中起作用：当激活或破坏该信号时，鳍骨元素会增加或减少。尾鳍也可再生，但与胸鳍相反，从刺猬抑制引起的逮捕释放后可恢复再生。对视黄酸处理后或在再生过程中改变刺猬信号水平后获得的鳍表型进行比较分析，使我们能够将肢体四足类同等片段分配给息肉翅的骨架结构，从而为自足类的起源提供线索。我们提出，肢体过渡期间，肢体的再生是脊椎动物的共同特征。

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  • 作者

    Rodrigo Cuervo; Rocio Hernandez-Martinez; Jesus Chimal-Monroy; Horacio Merchant-Larios; Luis Covarrubias;

  • 作者单位

    Department of Developmental Genetics and Molecular Physiology, Institute de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca,Morelos, 62210, Mexico,Facultad de Ciencias Biologicas y Agropecuarias, Universidad Veracruzana, Tuxpan, Veracruz, 92850, Mexico;

    Department of Developmental Genetics and Molecular Physiology, Institute de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca,Morelos, 62210, Mexico;

    Department of Cell Biology and Physiology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 04510 Mexico City, D.F., Mexico;

    Department of Cell Biology and Physiology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 04510 Mexico City, D.F., Mexico;

    Department of Developmental Genetics and Molecular Physiology, Institute de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca,Morelos, 62210, Mexico;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    development; evolution; actinopterygians; bichir;

    机译：发展演化;放线翅目比希尔;

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