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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The role of the small GTPase Rap in Drosophila R7 photoreceptor specification
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The role of the small GTPase Rap in Drosophila R7 photoreceptor specification

机译：小GTPase Rap在果蝇R7感光受体规格中的作用

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摘要

The Drosophila R7 photoreceptor provides an excellent model system with which to study how cells receive and "decode" signals that specify cell fate. R7 is specified by the combined actions of the receptor tyrosine kinase (RTK) and Notch (N) signaling pathways. These pathways interact in a complex manner that includes antagonistic effects on photoreceptor specification: RTK promotes the photoreceptor fate, whereas N inhibits. Although other photore-ceptors are subject to only mild N activation, R7 experiences a high-level N signal. To counter this effect and to ensure that the cell is specified as a photoreceptor, a high RTK signal is transduced in the cell. Thus, there are two levels of RTK transduction in the photo-receptors: in R7 it is high, whereas in others it is low. Here, we address how this high-level RTK signal is transduced in R7 and find that, in addition to Ras, another small GTPase, Rap, is also engaged. Thus, when N activity is high, a robust RTK signal operates that uses both Ras and Rap, but when N activity is low, only a mild RTK signal is transduced and Ras alone suffices for the purpose.
机译：果蝇R7感光体提供了一个出色的模型系统，可用于研究细胞如何接收和“解码”指定细胞命运的信号。 R7由受体酪氨酸激酶（RTK）和Notch（N）信号通路的联合作用确定。这些途径以复杂的方式相互作用，包括对感光体规格的拮抗作用：RTK促进了感光体的命运，而N则抑制了。尽管其他感光器仅受轻度N激活，但R7会经历高水平的N信号。为了抵消这种影响并确保将细胞指定为感光体，在细胞中转导了高RTK信号。因此，在感光器中有两种水平的RTK转导：在R7中为高，而在其他受体中为低。在这里，我们讨论了如何在R7中转换此高电平RTK信号，并且发现除了Ras外，另一个小GTPase Rap也参与了。因此，当N活性高时，使用Ras和Rap的鲁棒RTK信号将运行，但是当N活性低时，仅转导温和的RTK信号，仅Ras就足够了。

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