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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis
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Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis

机译：分泌的人类糖基-tRNA合成酶与ERK激活的肿瘤发生有关。

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摘要

The causes of cancerous tumors and the mechanisms behind immune system responses to them have been extensively studied.Still, we have limited understanding of the complete arsenal of natural defense systems against tumors (1). In this study, we made the surprising observation that a conventional component of the body's protein-synthesis machinery, not thought to have a connection to tumor defense, in fact plays a role in the suppression of specific cancers. This function was demonstrated in laboratory experiments on cells and separately in vivo in animals that bore tumors. The results may form the basis for potential cancer therapeutics.
机译：对癌性肿瘤的病因和免疫系统对其产生反应的机制进行了广泛的研究，但对自然防御系统对肿瘤的完整了解仍然有限（1）。在这项研究中，我们得出了令人惊讶的观察结果，即人体蛋白质合成机制的常规组成部分（不认为与肿瘤防御系统有关）实际上在抑制特定癌症中起作用。在患有肿瘤的动物的细胞实验以及体内实验中证明了这一功能。结果可能构成潜在癌症治疗的基础。

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    Min Chul Park; Taehee Kang; Da Jin; Jung Min Han; Sang Bum Kim; Yun Jung Park; Kiwon Cho; Young Woo Park; Min Guo; Weiwei He; Xiang-Lei Yang; Paul Schimmel; Sunghoon Kim;

  • 作者单位

    Medicinal Bioconvergence Research Center Seoul National University, Seoul 151-742, Korea;

    Medicinal Bioconvergence Research Center Seoul National University, Seoul 151-742, Korea;

    Medicinal Bioconvergence Research Center Seoul National University, Seoul 151-742, Korea;

    Medicinal Bioconvergence Research Center Seoul National University, Seoul 151-742, Korea;

    Medicinal Bioconvergence Research Center Seoul National University, Seoul 151-742, Korea;

    lntegrative Omics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea;

    Integrative Omics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea;

    Integrative Omics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea;

    Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458;

    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;

    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;

    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;

    Medicinal Bioconvergence Research Center, Seoul National University, Seoul 151-742, Korea World Class University Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Technology, Seoul National University, Seoul 151-742, Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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