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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Protein misinteraction avoidance causes highly expressed proteins to evolve slowly
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Protein misinteraction avoidance causes highly expressed proteins to evolve slowly

机译:避免蛋白质错配导致高表达的蛋白质缓慢进化

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摘要

A central question in evolutionary biology is what determines the rate of protein evolution. Extensive genomic studies have shown a strong negative correlation between the expression level of a protein and its rate of evolution (E-R anticorrelation) (1, 2). This important but puzzling relationship is currently explained by the protein misfolding avoidance1 hypothesis (2, 3). We show that this hypothesis is insufficient to explain the E-R anticorrelation, especially for protein surfaces. We propose and provide strong evidence for a hypothesis termed protein misinteraction avoidance.
机译:进化生物学中的一个核心问题是决定蛋白质进化速率的因素。广泛的基因组研究表明,蛋白质的表达水平与其进化速率(E-R反相关)之间具有很强的负相关性(1、2)。目前,这种重要但令人困惑的关系是通过避免蛋白质错误折叠的假说来解释的(2、3)。我们显示此假设不足以解释E-R反相关,尤其是对于蛋白质表面。我们提出并提供了强有力的证据来支持被称为蛋白质错配避免的假设。

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    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China,Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Ml 48109;

    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Ml 48109,Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, Republic of China;

    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Ml 48109;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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