...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Antigen-specific memory in B-1a and its relationship to natural immunity
【24h】

Antigen-specific memory in B-1a and its relationship to natural immunity

机译:B-1a中的抗原特异性记忆及其与自然免疫的关系

获取原文
获取原文并翻译 | 示例
           

摘要

In the companion article by Yang and colleagues [Yang Y, et al. (2012) Proc Natl Acad 5c/ USA, 109, 10.1073/pnas.1121631109], we have shown that priming with glycolipid (FtL) from Francisella tularensis live-vaccine strain (ⅰ) induces FtL-specific B-1a to produce robust primary responses (IgM IgG); (ⅱ) establishes persistent long-term production of serum IgM and IgG anti-FtL at natural antibody levels; and (ⅲ) elicits FtL-specific B-1a memory cells that arise in spleen but rapidly migrate to the peritoneal cavity, where they persist indefinitely but divide only rarely. Here, we show that FtL rechallenge alone induces these PerC B-1a memory cells to divide extensively and to express a unique activation signature. However, FtL rechallenge in the context of a Toll-like receptor 4 agonist-stimulated inflammatory response readily induces these memory cells to migrate to spleen and initiate production of dominant IgM anti-FtL secondary responses. Thus, studies here reveal unique mechanisms that govern B-1a memory development and expression, and introduce B-1a memory as an active participant in immune defenses. In addition, at a practical level, these studies suggest previously unexplored vaccination strategies for pathogen-associated antigens that target the B-1a repertoire.
机译:在杨及其同事的同伴文章中[Yang Y,et al。 (2012)Proc Natl Acad 5c / USA,109,10.1073 / pnas.1121631109],我们显示了用来自弗朗西斯菌的活疫苗菌株(ⅰ)的糖脂(FtL)引发引发FtL特异性B-1a产生强健的原代反应(IgM IgG); (ⅱ)建立以天然抗体水平持续长期产生血清IgM和IgG抗FtL的方法; (ⅲ)引起FtL特异性B-1a记忆细胞在脾脏中出现,但迅速迁移到腹膜腔,在那里它们无限期存在,但很少分裂。在这里,我们显示FtL再挑战独自诱导这些PerC B-1a记忆细胞广泛分裂并表达独特的激活特征。但是,在Toll样受体4激动剂刺激的炎症反应的情况下,FtL再挑战很容易诱导这些记忆细胞迁移至脾脏并开始产生主要的IgM抗FtL次级反应。因此,这里的研究揭示了控制B-1a记忆发育和表达的独特机制,并将B-1a记忆作为免疫防御的积极参与者。另外,在实践水平上,这些研究建议了针对B-1a组成部分的病原体相关抗原的先前未探索的疫苗接种策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号