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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates
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Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates

机译：转录因子Olig2定义了偏向特定细胞命运的视网膜祖细胞亚群

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摘要

Previous lineage analyses have shown that retinal progenitor cells (RPCs) are multipotent throughout development, and expression-profiling studies have shown a great deal of molecular heterogeneity among RPCs. To determine if the molecular heterogeneity predicts that an RPC will produce particular types of progeny, clonal lineage analysis was used to investigate the progeny of a subset of RPCs, those that express the basic helix-loop-helix transcription factor, Olig2. The embryonic Olig2~+ RPCs underwent terminal divisions, producing small clones with primarily two of the five cell types being made by the pool of RPCs at that time. The later, postnatal Olig2~+ RPCs also made terminal divisions, which were biased toward production of rod photoreceptors and amacrine cell inter-neurons. These data indicate that the multipotent progenitor pool is made up of distinctive types of RPCs, which have biases toward producing subsets of retinal neurons in a terminal division, with the types of neurons produced varying over time. This strategy is similar to that of the developing Drosophila melanogaster ventral nerve cord, with the Otig2~+ cells behaving as ganglion mother cells.
机译：先前的谱系分析表明，视网膜祖细胞（RPC）在整个发育过程中都是多能的，并且表达谱分析研究表明RPC之间存在很大的分子异质性。为了确定分子异质性是否预测RPC将产生特定类型的子代，使用克隆谱系分析来研究RPC子集的子代，这些子集表达基本的螺旋-环-螺旋转录因子Olig2。胚胎的Olig2〜+ RPC经历了末端分裂，产生了小的克隆，当时五种细胞类型中的两种主要由RPC池产生。后来，产后的Olig2 + RPC也进行了末端分裂，这倾向于产生棒状感光细胞和无长突细胞间神经元。这些数据表明，多能祖细胞由独特的RPC类型组成，这些RPC倾向于在终末分裂中产生视网膜神经元的子集，并且所产生的神经元的类型随时间而变化。该策略类似于正在发育的果蝇腹侧神经索，Otig2〜+细胞表现为神经节母细胞。

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  • 作者

    Brian P. Hafler; Natalia Surzenko; Kevin T. Beier; Claudio Punzo; Jeffrey M. Trimarchi; Jennifer H. Kong; Constance L. Cepko;

  • 作者单位

    Department of Genetics, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology, and Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510;

    Department of Genetics, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology, and Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;

    Department of Genetics, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology, and Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;

    Department of Genetics, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology, and Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology and Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01606;

    Department of Genetics, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology, and Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115 Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011;

    Department of Neurobiology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095;

    Department of Genetics, Harvard Medical School, Boston, MA 02115 Department of Ophthalmology, and Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    neura; progenitors; neural development; oligodendrocyte transcription factor 2;

    机译：神经质祖细胞神经发育少突胶质细胞转录因子2;

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