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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Bisphenol A alters the development of the rhesus monkey mammary gland
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Bisphenol A alters the development of the rhesus monkey mammary gland

机译：双酚A改变恒河猴乳腺的发育

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The xenoestrogen bisphenol A (BPA) used in the manufacturing of various plastics and resins for food packaging and consumer products has been shown to produce numerous endocrine and developmental effects in rodents. Exposure to low doses of BPA during fetal mammary gland development resulted in significant alterations in the gland's morphology that varied from subtle ones observed during the exposure period to precancerous and cancerous lesions manifested in adulthood. This study assessed the effects of BPA on fetal mammary gland development in nonhu-man primates. Pregnant rhesus monkeys were fed 400 ng of BPA per kg of body weight daily from gestational day 100 to term, which resulted in 0.68 ± 0.312 ng of unconjugated BPA per mL of maternal serum, a level comparable to that found in humans. At birth, the mammary glands of female offspring were removed for morphological analysis. Morphological parameters similar to those shown to be affected in rodents exposed prenatally to BPA were measured in whole-mounted glands; estrogen receptor (ER) a and f) expression were assessed in paraffin sections. Student's f tests for equality of means were used to assess differences between exposed and unexposed groups. The density of mammary buds was significantly increased in BPA-exposed monkeys, and the overall development of their mammary gland was more advanced compared with unexposed monkeys. No significant differences were observed in ER expression. Altogether, gestational exposure to the estrogen-mimic BPA altered the developing mammary glands of female nonhuman primates in a comparable manner to that observed in rodents.
机译：已经证明，用于制造食品包装和消费品的各种塑料和树脂的异雌激素双酚A（BPA）在啮齿动物中产生多种内分泌和发育作用。胎儿乳腺发育过程中暴露于低剂量的BPA会导致腺体形态发生重大变化，从暴露期间观察到的细微变化到成年后表现出的癌前病变和癌性病变。这项研究评估了BPA对非人类灵长类动物的胎儿乳腺发育的影响。从妊娠第100天到足月，妊娠恒河猴每天每公斤体重饲喂400 ng BPA，每毫升母体血清产生0.68±0.312 ng未结合的BPA，这一水平与人类的水平相当。出生时，将雌性后代的乳腺切除以进行形态学分析。在整个安装的腺体中测量了类似于在产前暴露于BPA的啮齿动物中受影响的形态学参数。在石蜡切片中评估雌激素受体（ER）a和f）的表达。使用学生的均值均等性f检验来评估暴露和未暴露组之间的差异。与未接触BPA的猴子相比，接触BPA的猴子的乳芽密度显着增加，并且其乳腺的整体发育更加先进。在ER表达中未观察到显着差异。总的来说，妊娠暴露于类似雌激素的双酚A可以改变雌性非人类灵长类动物的乳腺发育，其方式与啮齿类动物相似。

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