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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca~(2+)-activated K~+ (BK) channels
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Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca~(2+)-activated K~+ (BK) channels

机译：蛛网膜下腔血液逆转神经血管耦合取决于大电导Ca〜（2+）激活的K〜+（BK）通道

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摘要

Aneurysmal subarachnoid hemorrhage (SAH)-strokes involving cerebral aneurysms that rupture and release blood onto the brain surface-are associated with high rates of death and disability. The cellular events contributing to ischemic neurological damage following SAH remain unknown (1). Here, we report that subarachnoid blood profoundly impacts communication within the neurovascular unit (neurons, astrocytes, and arterioles) causing pathological vasoconstriction of intracerebral (parenchymal) arterioles.
机译：涉及脑动脉瘤的动脉瘤蛛网膜下腔出血（SAH）中风破裂并向脑表皮释放血液，这与高死亡率和致残率相关。 SAH后导致缺血性神经系统损害的细胞事件仍然未知（1）。在这里，我们报告蛛网膜下腔血深刻影响神经血管单元（神经元，星形胶质细胞和小动脉）内的通讯，从而引起脑（实质）小动脉的病理性血管收缩。

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    Masayo Koide; Adrian D. Bonev; Mark T. Nelson; George C. Wellman;

  • 作者单位

    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405;

    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405;

    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, Institute of Cardiovascular Sciences,University of Manchester, Manchester Ml 3 9NT, United Kingdom;

    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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