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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CCAAT/enhancer-binding protein 5 facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner
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CCAAT/enhancer-binding protein 5 facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

机译：CCAAT /增强子结合蛋白5以血小板活化因子受体依赖性方式促进肺炎球菌性肺炎期间的细菌传播

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摘要

CCAAT/enhancer-binding protein 6 (C/EBPS) recently emerged as an essential player in the inflammatory response to bacterial infections. C/EBP8 levels increase rapidly after a proinflammatory stimulus, and increasing C/EBPδ levels seem to be indispensable for amplification of the inflammatory response. Here we aimed to elucidate the role of C/EBPS in host defense in community-acquired pneumococcal pneumonia. We show that C/EBPδ~(-/-) mice are relatively resistant to pneumococcal pneumonia, as indicated by delayed and reduced mortality, diminished outgrowth of pneumococci in lungs, and reduced dissemination of the infection. Moreover, expression of platelet-activating factor receptor (PAFR), which is known to potentiate bacterial translocation of Gram-positive bacteria, was significantly reduced during infection in C/EBP8δ~(-/-) mice compared with WT controls. Importantly, cell stimulation experiments revealed that C/EBPS potentiates PAFR expression induced by lipoteichoic acid and pneumococci. Thus, C/EBPS exaggerates bacterial dissemination during Streptococcus pneumon/ae-induced pulmonary infection, suggesting an important role for PAFR-depen-dent bacterial translocation.
机译：CCAAT /增强子结合蛋白6（C / EBPS）最近成为细菌感染的炎症反应中的重要角色。 C / EBP8水平在促炎刺激后迅速增加，而C /EBPδ水平的升高似乎对于炎症反应的放大是必不可少的。在这里，我们旨在阐明C / EBPS在社区获得性肺炎球菌性肺炎的宿主防御中的作用。我们显示，C /EBPδ〜（-/-）小鼠对肺炎球菌性肺炎具有相对抗性，如延迟和降低的死亡率，肺炎性肺炎球菌的生长减少以及感染传播的减少所表明。此外，与WT对照相比，在感染C /EBP8δ〜（-/-）小鼠期间，血小板活化因子受体（PAFR）的表达显着降低，该表达可增强革兰氏阳性细菌的细菌易位。重要的是，细胞刺激实验表明，C / EBPS增强了脂磷壁酸和肺炎球菌诱导的PAFR表达。因此，C / EBPS在肺炎链球菌/ ae诱导的肺部感染期间夸大了细菌的传播，提示了PAFR依赖性细菌易位的重要作用。

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    JanWillem Duitman; Marcel Schouten; Angelique P. Groot; Joost B. Daalhuisen; Sandrine Florquin; Tom van der Poll; C. Arnold Spek;

  • 作者单位

    Center for Experimental and Molecular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

    Center for Experimental and Molecular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

    Center for Experimental and Molecular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

    Center for Experimental and Molecular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

    Department of Pathology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

    Center for Experimental and Molecular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

    Center for Experimental and Molecular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    lung barrier; tanscytosis;

    机译：肺屏障转胞吞作用;

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