...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Exposure therapy triggers lasting reorganization of neural fear processing
【24h】

Exposure therapy triggers lasting reorganization of neural fear processing

机译：暴露疗法引发神经恐惧处理的持久重组

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A single session of exposure therapy can eliminate recalcitrant and disabling fear of phobogenic objects or situations. We studied neural mechanisms of this remarkable outcome by monitoring changes in brain activity as a result of successful 2-h treatment. Before treatment, phobogenic images excited activity in a network of regions, including amygdala, insula, and cingulate cortex, relative to neutral images. Successful therapy dampened responsiveness in this fear-sensitive network while concomitantly heightening pre-frontal involvement. Six months later, dampened fear-network activity persisted but without prefrontal engagement. Additionally, individual differences in the magnitude of visual cortex activations recorded shortly after therapy predicted therapeutic outcomes 6 mo later, which involved persistently diminished visual responsiveness to phobogenic images. Successful therapy thus entailed stable reorganization of neural responses to initially feared stimuli. These effects were linked to fear-extinction mechanisms identified in animal models, thus opening new opportunities for the treatment and prevention of debilitating anxiety disorders.
机译：一次暴露疗法可以消除顽固症并消除对光化物或情况的恐惧。我们通过监测成功2小时治疗后大脑活动的变化，研究了这一显着结果的神经机制。在处理之前，相对于中性图像，光致图像激发了包括杏仁核，岛状岛和扣带回皮层在内的区域网络的活动。成功的治疗会减弱这个对恐惧敏感的网络的反应能力，同时会增加前额叶的受累。六个月后，恐惧网络活动持续减弱，但没有前额接触。此外，治疗后不久记录的视觉皮层激活程度的个体差异预测了治疗后6个月的治疗结果，这涉及到持续不断的视觉减弱对光致图像的反应。因此，成功的治疗需要对最初担心的刺激神经反应进行稳定的重组。这些影响与在动物模型中确定的消除恐惧的机制有关，从而为治疗和预防使人衰弱的焦虑症提供了新的机会。

著录项

  • 来源
  • 作者

    Katherina K. Hauner; Susan Mineka; Joel L. Voss; Ken A. Paller;

  • 作者单位

    Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 Department of Psychology, Northwestern University, Evanston, IL 60208;

    Department of Psychology, Northwestern University, Evanston, IL 60208;

    Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

    Department of Psychology, Northwestern University, Evanston, IL 60208 Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    emotion; functional MRI; specific phobia;

    机译：情感;功能性MRI;特定恐惧症;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号