...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension
【24h】

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension

机译：沉默纺锤体装配检查点而没有正常的伸线肌张力，容易出错的哺乳动物雌性减数分裂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Meiosis I in human females is error-prone and is a leading cause of spontaneous abortion and congenital defects (1). Errors in meiotic chromosome segregation lead to the formation of aneuploid eggs, greatly compromising embryo development. It is now generally accepted that the spindle assembly checkpoint, also known as the mitotic/meiotic checkpoint, acts during meiosis I in mouse oocytes to ensure successful attachment of the kinet-ochores of homologously paired bivalent chromosomes. The molecular switch that silences the female meiotic checkpoint, as well as its robustness to prevent premature anaphase I, has not been tested. Efforts in male meiosis in insects have established that despite attachment to spindle microtubules, a single unpaired homolog provokes chronic spindle assembly checkpoint-dependent meiotic arrest that is overcome by application of mechanical tension to the kinetochore of the unpaired homolog (2).
机译：人类女性的减数分裂I容易出错，并且是自然流产和先天性缺陷的主要原因（1）。减数分裂染色体分离错误导致非整倍体卵的形成，极大地损害了胚胎的发育。现在已经普遍接受的是纺锤体装配检查点，也称为有丝分裂/减数分裂检查点，在小鼠卵母细胞减数分裂I期间起作用，以确保成功配对同源配对的二价染色体的动粒。使雌性减数分裂检查点沉默的分子开关及其防止过早后期I的坚固性尚未经过测试。昆虫对雄性减数分裂的努力已经确定，尽管附着在纺锤体微管上，但单个未配对的同源物仍会引起慢性纺锤体组装检查点依赖性的减数分裂阻滞，而对非配对同系物的动粒施加机械张力可以克服这种减数分裂现象（2）。

著录项

  • 来源
  • 作者

    Agnieszka Kolano; Stephane Brunet; Alain D. Silk; Don W. Cleveland; Marie-Helene Verlhac;

  • 作者单位

    Centre Interdisciplinaire de Recherche en Biologie, Unite Mixte de Recherche-Centre National de la Recherche Scientifique 7241/Institut National de la Sante et de la Recherche Medicate U1050, College de France, 75005 Paris,France Memolife Laboratory of Excellence and Paris Science Lettre, 75005 Paris, France;

    Centre Interdisciplinaire de Recherche en Biologie, Unite Mixte de Recherche-Centre National de la Recherche Scientifique 7241/Institut National de la Sante et de la Recherche Medicate U1050, College de France, 75005 Paris,France Memolife Laboratory of Excellence and Paris Science Lettre, 75005 Paris, France;

    Knight Cancer Institute and Department of Dermatology, Oregon Health and Science University, Portland, OR 97239 Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093;

    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093;

    Centre Interdisciplinaire de Recherche en Biologie, Unite Mixte de Recherche-Centre National de la Recherche Scientifique 7241/Institut National de la Sante et de la Recherche Medicate U1050, College de France, 75005 Paris,France Memolife Laboratory of Excellence and Paris Science Lettre, 75005 Paris, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号