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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments
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The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

机译：N端规则途径通过破坏凋亡蛋白片段来抵消细胞死亡

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摘要

In the course of apoptosis, caspases cleave ~500-1,000 different proteins in a mammalian cell (1, 2). A small subset of the resulting protein fragments comprises polypeptides with proapoptotic activity, defined as those polypeptides that increase the probability of apoptosis compared with full-length precursors. Previous studies identified ~20 caspase-generated proapoptotic fragments of mammalian proteins. In contrast to activated caspases, which can be counteracted by members of the inhibitor of apoptosis protein family, there is virtually no understanding of cellular responses to proapoptotic protein fragments. One possibility is the regulation of proapoptotic fragments by their selective degradation. We report here that at least 10 known proapoptotic fragments are short-lived substrates of the Arg/N-end rule pathway.
机译：在凋亡过程中，半胱天冬酶在哺乳动物细胞中裂解约500-1,000种不同的蛋白质（1、2）。所得蛋白质片段的一小部分包含具有促凋亡活性的多肽，定义为与全长前体相比增加凋亡可能性的那些多肽。先前的研究确定了约20个半胱天冬酶产生的哺乳动物蛋白的凋亡片段。与活化的胱天蛋白酶相反，活化的胱天蛋白酶可以被凋亡蛋白家族的抑制剂所抵消，实际上对细胞对凋亡蛋白片段的反应没有任何了解。一种可能性是通过其选择性降解来调节细胞凋亡片段。我们在这里报告说，至少10个已知的凋亡片段是Arg / N端规则途径的短时底物。

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