PIP_2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker

Aldo A. Rodriguez-Menchaca; Scott K. Adney; Qiong-Yao Tang; Xuan-Yu Meng; Avia Rosenhouse-Dantsker; Meng Cui; Diomedes E. Logothetis

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PIP_2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker

机译：PIP_2通过S4-S5连接器控制电压传感器的移动和Kv通道的开孔

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Voltage-gated potassium (Kv) channels are involved in diverse physiological processes, including action potential re-polarization, secretion of hormones and neurotransmitters, and contraction of skeletal muscle (1). These channels regulate the flow of potassium ions across the plasma membrane in response to changes in membrane potential and are regulated by several factors, such as posttranslational modifications and membrane lipids.

机译：电压门控钾（Kv）通道涉及多种生理过程，包括动作电位重新极化，激素和神经递质的分泌以及骨骼肌的收缩（1）。这些通道响应膜电位的变化调节钾离子跨质膜的流动，并受几种因素的调节，例如翻译后修饰和膜脂。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第36期|p.14299-14300|共2页
作者
Aldo A. Rodriguez-Menchaca; Scott K. Adney; Qiong-Yao Tang; Xuan-Yu Meng; Avia Rosenhouse-Dantsker; Meng Cui; Diomedes E. Logothetis;
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作者单位

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298,Departamento de Fisiologia y Biofisica, Facultad de Medicina, Universi-dad Aut6noma de San Luis Potosi, San Luis Potosi, SLP 78210, Mexico;

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298;

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298;

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298;

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298,Pulmonary Section, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612;

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298;

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Conservation analysis of residues in the S4-S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling [J] . Balleza Daniel, Carrillo Elisa, Gomez-Lagunas Froylan Pfluegers Archiv: European Journal of Physiology . 2015,第10期

机译：Kv和HCN通道中S4-S5连接子和S5-P-S6孔模数末端的残基的保守性分析：机电耦合的灵活决定因素
2. Involvement of the S4-S5 linker and the C-linkerdomain regions to voltage-gating in plantShaker channels: Comparison with animalHCN and Kv channels [J] . Manuel Nieves-Cordones, Isabelle Gaillard Plant signaling & behavior . 2014,第10期

机译：S4-S5接头和C-接头结构域区域参与植物摇床通道的电压门控：与动物HCN和Kv通道的比较
3. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR [J] . ZhangJ., QuX., CovarrubiasM., Biochimica et biophysica acta. Biomembranes . 2013,第2期

机译：通过全身麻醉剂深入了解Shaw2 Kv通道的调节：通过胶束对S4-S5接头和S6 C端肽的结构和功能研究
4. Regular Nano-Pores Fabricated By UV Cross-Linking Non-softbaked SU-8 Resist In a Solvent Evaporation Controlled Environment [C] . Chia-Jung Chang, Fan-Gang Tseng, Chung-Shi Yang NSTI Nanotechnology Conference and Trade Show(NSTI Nanotech 2005) vol.1; 20050508-12; Anaheim,CA(US) . 2005

机译：UV交联非软烤SU-8制成的常规纳米孔可在溶剂蒸发控制的环境中抵抗
5. Gating of the sensory neuronal voltage-gated sodium channel Nav1.7: Analysis of the role of D3 and D4/S4-S5 linkers in transition to an inactivated state. [D] . Jarecki, Brian W. 2010

机译：感觉神经元电压门控钠通道Nav1.7的门控：分析D3和D4 / S4-S5接头在转变为失活状态时的作用。
6. PNAS Plus: PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker [O] . Aldo A. Rodriguez-Menchaca, Scott K. Adney, Qiong-Yao Tang, 2012

机译：PNAS Plus：PIP2通过S4–S5连接器控制电压传感器的移动和Kv通道的开孔
7. Involvement of the S4-S5 linker and the C-linker domain regions to voltage-gating in plant Shaker channels: comparison with animal HCN and Kv channels. [O] . Nieves-Cordones, Manuel, Gaillard, Isabelle 2013

机译：S4-S5接头和C接头结构域区域参与植物振荡器通道的电压门控：与动物HCN和Kv通道的比较。

PIP_2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker

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