...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Weak temporal signals can synchronize and accelerate the transition dynamics of biopolymers under tension
【24h】

Weak temporal signals can synchronize and accelerate the transition dynamics of biopolymers under tension

机译：短暂的时间信号会在张力下同步并加速生物聚合物的转变动力学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In addition to thermal noise, which is essential to promote confor-mational transitions in biopolymers, the cellular environment is replete with a spectrum of athermal fluctuations that are produced from a plethora of active processes. To understand the effect of athermal noise on biological processes, we studied how a small oscillatory force affects the thermally induced folding and unfolding transition of an RNA hairpin, whose response to constant tension had been investigated extensively in both theory and experiments. Strikingly, our molecular simulations performed under overdamped condition show that even at a high (low) tension that renders the hairpin (un)folding improbable, a weak external oscillatory force at a certain frequency can synchronously enhance the transition dynamics of RNA hairpin and increase the mean transition rate. Furthermore, the RNA dynamics can still discriminate a signal with resonance frequency even when the signal is mixed among other signals with nonresonant frequencies. In fact, our computational demonstration of thermally induced resonance in RNA hairpin dynamics is a direct realization of the phenomena called stochastic resonance and resonant activation. Our study, amenable to experimental tests using optical tweezers, is of great significance to the folding of biopolymers in vivo that are subject to the broad spectrum of cellular noises.
机译：除了对于促进生物聚合物中构型转变必不可少的热噪声外，细胞环境还充斥着由大量活跃过程产生的一系列无热波动。为了了解无热噪声对生物过程的影响，我们研究了小的振荡力如何影响RNA发夹的热诱导折叠和展开转变，在理论和实验中都对RNA对发夹的响应进行了广泛研究。令人惊讶的是，我们在过度阻尼条件下进行的分子模拟表明，即使在高（低）张力下使发夹（解开）折叠变得不可能的情况下，在一定频率下弱的外部振荡力也可以同步增强RNA发夹的转变动力学并增加RNA的发夹。平均过渡率。此外，即使信号在具有非共振频率的其他信号中混合，RNA动力学仍然可以区分具有共振频率的信号。实际上，我们在RNA发夹动力学中的热诱导共振的计算论证是对被称为随机共振和共振激活的现象的直接实现。我们的研究适用于使用光镊的实验测试，这对于受到细胞噪声影响的体内生物聚合物折叠具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号