AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia

Yong-Seok Lee; Sun-Lim Choi; Heejung Jun; Se-Jeong Yim; Jin-A Lee; Hyoung F. Kim; Seung-Hee Lee; Jaehoon Shim; Kyungmin Lee; Deok-Jin Jang; Bong-Kiun Kaang

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AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia

机译：富含AU的元素结合蛋白在海long的长期突触可塑性过程中负调节CCAAT增强子结合蛋白mRNA的稳定性

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The consolidation of long-term memory for sensitization and synaptic facilitation in Aplysia requires synthesis of new mRNA including the immediate early gene Aplysia CCAAT enhancer-binding protein (ApC/EBP). After the rapid induction of ApC/EBP expression in response to repeated treatments of 5-hydroxytryptamine (5-HT), ApC/EBP mRNA is temporarily expressed in sensory neurons of sensory-to-motor synapses. However, the molecular mechanism underlying the rapid degradation of ApC/EBP transcript is not known. Here, we cloned an AU-rich element (ARE)-binding protein, ApAUFI, which functions as a destabilizing factor for ApC/EBP mRNA. ApAUFI was found to bind to the 3' UTR of ApC/EBP mRNA that contains AREs and subsequently reduces the expression of ApC/EBP 3' UTR-containing reporter genes. Moreover, overexpres-sion of ApAUFI inhibited the induction of ApC/EBP mRNA in sensory neurons and also impaired long-term facilitation of sensory-to-motor synapses by repetitive 5-HT treatments. These results provide evidence for a critical role of the posttranscriptional modification of ApC/EBP mRNA during the consolidation of synaptic plasticity.

机译：为了增强海藻中的敏化和突触促进作用而长期记忆的巩固需要合成新的mRNA，包括立即的早期基因海藻CCAAT增强子结合蛋白（ApC / EBP）。在响应5-羟基色胺（5-HT）的重复治疗快速诱导ApC / EBP表达后，ApC / EBP mRNA暂时在感觉运动突触的感觉神经元中表达。但是，ApC / EBP转录物快速降解的分子机制尚不清楚。在这里，我们克隆了一个富含AU的元素（ARE）结合蛋白ApAUFI，它充当ApC / EBP mRNA的去稳定化因子。发现ApAUFI与含有ARE的ApC / EBP mRNA的3'UTR结合，并随后降低了含有ApC / EBP 3'UTR的报道基因的表达。此外，ApAUFI的过度表达抑制了感官神经元中ApC / EBP mRNA的诱导，并且通过重复的5-HT治疗也损害了感觉-运动突触的长期促进作用。这些结果提供证据表明，在突触可塑性的巩固过程中，ApC / EBP mRNA的转录后修饰至关重要。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第38期|p.15520-15525|共6页
作者
Yong-Seok Lee; Sun-Lim Choi; Heejung Jun; Se-Jeong Yim; Jin-A Lee; Hyoung F. Kim; Seung-Hee Lee; Jaehoon Shim; Kyungmin Lee; Deok-Jin Jang; Bong-Kiun Kaang;
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National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

Department of Biotechnology, College of Life Science and Nano Technology, Hannam University, Daejeon 305-811, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea;

Department of Anatomy, Graduate School of Medicine, Brain Science and Engineering Institute, Kyungpook National University, Daegu 700-422, Korea;

Department of Applied Biology, College of Ecology and Environment, Kyungpook National University, Sangju 742-711, Korea;

National Creative Research Initiative Center for Memory, Departments of Biological Sciences Seoul National University, Seoul 151-747, Korea,Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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专利

1. Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. [J] . Yim SJ, Lee YS, Lee JA, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2006,第2期

机译：富含Aplysia AU的元素结合蛋白ApELAV对ApC / EBP mRNA的调节及其对5-羟色胺诱导的长期促进的作用。
2. Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein (beta) and (delta) Co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation. [J] . Taubenfeld SM, Wiig KA, Monti B, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2001,第1期

机译：海马CCAAT增强子结合蛋白（β）和δ的Fornix依赖性诱导与磷酸化的cAMP反应元件结合蛋白共定位，并伴随长期记忆巩固。
3. Cyclic adenosine 3',5'-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. [J] . Hsu CC, Lu CW, Huang BM, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2008,第2期

机译：环状腺苷3'，5'-单磷酸反应元件结合蛋白和CCAAT /增强子结合蛋白介导前列腺素E2诱导的子宫内膜异位症基质细胞中类固醇生成的急性调节蛋白表达。
4. CCAAT/Enhancer-Binding Protein Beta Controls Differentiation-Specific Expression of Chromatin Remodeling Factor BRM [C] . Toshinari Itoh, Katsuhide Miyake, Shinji Iijima Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：CCAAT / Enhancer结合蛋白β控制染色质重塑因子BRM的分化特异性表达
5. Role of adducins, actin-regulating proteins, in synaptic plasticity and learning. [D] . Rabenstein, Rebecca Lynn. 2007

机译：Adducins，肌动蛋白调节蛋白在突触可塑性和学习中的作用。
6. AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia [O] . Yong-Seok Lee, Sun-Lim Choi, Heejung Jun, 2012

机译：富含AU的元素结合蛋白在海long的长期突触可塑性过程中负调节CCAAT增强子结合蛋白mRNA的稳定性
7. AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia [O] . Yong-Seok Lee, Sun-Lim Choi, Heejung Jun, 2012

机译：富含Au的元素结合蛋白负调节CCAAT增强剂结合蛋白mRNA蛋白mRNA蛋白酶mRNA稳定性，可在APLYSIA中的长期突触可塑性
8. Activation of Mitogen-Activated Protein Kinases and Cyclic Amp Response Element-Binding Protein in Synaptic Plasticity. [R] . Voulalas, P. J. 1997

机译：突触可塑性中丝裂素活化蛋白激酶和环状放大器反应元件结合蛋白的激活。

AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia

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