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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering
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Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering

机译:无头副流感病毒5血凝素神经氨酸酶茎杆的融合激活提示了触发的模块化机制

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摘要

Paramyxoviruses insert their genomes into cells by fusing their membrane envelope to target cell membranes. This fusion is mediated by two viral surface glycoproteins. The fusion protein (F) inserts a hydro- phobic fusion peptide into the cell membrane and undergoes a series of structural rearrangements to merge the membranes, and the receptor-binding protein (HN, H, or G) binds the cell's virus receptor, interacts with F, and synchronizes the refolding of F and fusion peptide insertion, a process known as "F activation" (1, 2).
机译:副粘病毒通过将其膜包膜融合到靶细胞膜上而将其基因组插入细胞。这种融合是由两种病毒表面糖蛋白介导的。融合蛋白(F)将疏水融合肽插入细胞膜,并经历一系列结构重排以融合膜,而受体结合蛋白(HN,H或G)结合细胞的病毒受体,相互作用与F并同步F的重新折叠和融合肽的插入,这一过程称为“ F激活”(1、2)。

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    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208;

    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208;

    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208,Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208;

    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208,Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208;

    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;

    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208,Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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