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Orderly wheels of the cyanobacterial clock

机译:蓝细菌时钟的有序轮

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摘要

Circadian rhythms, self-sustaining oscillations in an organism's behavior that repeat roughly once per day, have fascinated biologists for hundreds of years (1, 2). Part of this fascination comes from the fact that the existence of intrinsic biological rhythms implies that an organism carries within it a model of how it expects the external world to behave-a plant that moves its leaves in anticipation of the sun even when grown in constant conditions must have some hard-wired knowledge of the rotation of the Earth. Fundamentally, these predictive biological rhythms must originate mechanistically from carefully regulated molecular interactions that generate oscillations. In PNAS, Chang et al. (3) present a series of cleverly designed structural and biochemical experiments that shed light on the inner workings of the best-defined biological clock, the KaiABC protein oscillator.
机译:昼夜节律,生物体行为的自我维持振荡(每天大约重复一次)使生物学家着迷了数百年(1、2)。这种迷恋的部分原因是,内在的生物节律的存在暗示着有机体在其内部携带着一种模型,该模型期望外部世界如何运转-即使在恒定的环境中生长,植物也会在预期到阳光的情况下移动其叶子条件必须对地球自转有一定的认识。从根本上讲,这些预测性生物节律必须从机制上源于经过仔细调节的产生振荡的分子相互作用。在PNAS中,Chang等人。 (3)提出了一系列巧妙设计的结构和生化实验,以阐明最佳定义的生物钟KaiABC蛋白振荡器的内部工作原理。

著录项

  • 来源
  • 作者

    Michael J. Rust;

  • 作者单位

    Department of Molecular Genetics and Cell Biology, Institute for Oenomics and Systems Biology, University of Chicago, Chicago, IL 60637;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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