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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation
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Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation

机译：内部核糖体进入位点（IRES）介导的翻译激活在胶质母细胞瘤中c-Jun的异常表达

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摘要

The protooncogene c-Jun is a transcription factor that forms a variety of dimeric complexes collectively known as activator protein-1. It has been identified as the cellular homolog of the retroviral oncogene v-Jun and found to play a central role in the process of cell proliferation, cell death, and tumor progression (1). Expression of c-Jun is mainly transcriptionally controlled. It can be elevated by a diverse array of extracellular stimuli, including growth factors, cytokines, oxida-tive stress, and UV irradiation, which activate the MAPK signaling pathway and induce transcription of the c-Jun gene (2). Although c-Jun possesses onco-genic activity and contributes to the development and progression of tumors in animal models, DNA microarray screens, which measure mRNA expression levels, have identified only few human cancer types with aberrant expression of c-Jun. Here, we showed that c-Jun accumulation is elevated robustly in human glioblas-tomas and that this increase is not transcriptionally but, rather, translationally controlled.
机译：原癌基因c-Jun是一种转录因子，可形成多种二聚体复合物，统称为激活蛋白-1。它已被确定为逆转录病毒癌基因v-Jun的细胞同源物，并在细胞增殖，细胞死亡和肿瘤进展过程中起着核心作用（1）。 c-Jun的表达主要受转录控制。它可以通过各种各样的细胞外刺激来升高，包括生长因子，细胞因子，氧化应激和紫外线照射，这些活化因子激活MAPK信号传导途径并诱导c-Jun基因的转录（2）。尽管c-Jun具有致癌基因的活性并有助于动物模型中肿瘤的发展和进展，但是可测量mRNA表达水平的DNA微阵列筛查仅发现了少数c-Jun表达异常的人类癌症类型。在这里，我们显示了c-Jun积累在人神经胶质瘤中稳步提高，并且这种增加不是转录控制的，而是翻译控制的。

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    Lior Blau; Revital Knirsh; Iris Ben-Dror; Sivan Oren; Silke Kuphal; Peter Hau; Martin Proescholdt; Anja-Katrin Bosserhoff; Lily Vardimon;

  • 作者单位

    Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;

    Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;

    Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;

    Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;

    Institute of Pathology and Departments of University and University Hospital of Regensburg, 93053 Regensburg, Germany;

    Institute of Neurology , University and University Hospital of Regensburg, 93053 Regensburg, Germany;

    Institute of Neurosurgery, University and University Hospital of Regensburg, 93053 Regensburg, Germany;

    Institute of Pathology and Departments of University and University Hospital of Regensburg, 93053 Regensburg, Germany;

    Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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