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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
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Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

机译：统计连通性为新皮层神经微电路中的特定功能连通性提供了足够的基础

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摘要

A synaptic connection between any two cortical neurons is composed of multiple synapses formed by the axon of the pre-synaptic neuron and distributed along the axon, soma, and den-drites of the postsynaptic neuron. During development, a broad range of molecular signaling mechanisms act to form the neocortical layers by positioning the neurons, projecting their axonal and dendritic fibers, and forming selective synaptic connections between neurons. Molecular mechanisms also contribute to the activity-triggered formation of synapses between specific pairs of neurons. Thus, synapses are differentially distributed in a selective manner depending on the cell types being connected.
机译：任意两个皮质神经元之间的突触连接由突触前神经元的轴突形成并沿突触后神经元的轴突，躯体和树突分布的多个突触组成。在发育过程中，广泛的分子信号传导机制通过定位神经元，投射其轴突和树突状纤维并在神经元之间形成选择性的突触连接来形成新皮层。分子机制也有助于特定神经元对之间的突触形成活动触发。因此，根据所连接的细胞类型，突触以选择性的方式差异分布。

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    Sean L. Hill; Yun Wang; Imad Riachi; Felix Schuermann; Henry Markram;

  • 作者单位

    Blue Brain Project Brain Mind Institute, Ecole Polytechnique Federate de Lausanne, CH-1015 Lausanne, Switzerland;

    School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China,Steward St. Elizabeth's Medical Center, Tufts University, Boston, MA 02135;

    Blue Brain Project Brain Mind Institute, Ecole Polytechnique Federate de Lausanne, CH-1015 Lausanne, Switzerland;

    Blue Brain Project Brain Mind Institute, Ecole Polytechnique Federate de Lausanne, CH-1015 Lausanne, Switzerland;

    Blue Brain Project Brain Mind Institute, Ecole Polytechnique Federate de Lausanne, CH-1015 Lausanne, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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