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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Grid cell firing patterns signal environmental novelty by expansion
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Grid cell firing patterns signal environmental novelty by expansion

机译：网格单元点火模式通过扩展来传达环境新颖性

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摘要

The hippocampal formation plays key roles in representing an animal's location'and in detecting environmental novelty to create or update those representations. However, the mechanisms behind this latter function are unclear. Here, we show that environmental novelty causes the spatial firing patterns of grid cells to expand in scale and reduce in regularity, reverting to their familiar scale as the environment becomes familiar. Simultaneously recorded place cell firing fields remapped and showed a smaller, temporary expansion. Grid expansion provides a potential mechanism for novelty signaling and may enhance the formation of new hippocampal representations, whereas the subsequent slow reduction in scale provides a potential familiarity signal.
机译：海马结构在代表动物的位置和检测环境新颖性以创建或更新这些表示中起着关键作用。然而，后者功能背后的机制尚不清楚。在这里，我们表明环境的新颖性导致网格单元的空间激发模式在规模上扩大而在规律性上降低，随着环境变得熟悉而恢复为它们熟悉的规模。同时记录的位置细胞发射场重新映射并显示出较小的临时扩展。网格扩展为新颖信号提供了一种潜在的机制，并可能增强新海马代表的形成，而随后缓慢的规模减小提供了潜在的熟悉信号。

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  • 作者

    Caswell Barry; Lin Lin Ginzberg; John OKeefe; Neil Burgess;

  • 作者单位

    UCL Institutes of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom,UCL Institutes of Behavioural Neuroscience, and University College London, London WC1N 3AR, United Kingdom,UCL Institutes of Neurology, University College London, London WC1N 3AR, United Kingdom;

    UCL Institutes of Behavioural Neuroscience, and University College London, London WC1N 3AR, United Kingdom,UCL Institutes of Department of Cell and Developmental Biology, and University College London, London WC1N 3AR, United Kingdom;

    UCL Institutes of Department of Cell and Developmental Biology, and University College London, London WC1N 3AR, United Kingdom,UCL Institutes of Sainsbury-Wellcome Centre for Neural Circuits and Behaviour, University College London, London WC1N 3AR, United Kingdom;

    UCL Institutes of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom,UCL Institutes of Neurology, University College London, London WC1N 3AR, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    single unit; spatial memory; hippocampus;

    机译：单个单元空间记忆海马;

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