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Chemical physics of protein folding

机译：蛋白质折叠的化学物理学

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摘要

In 2008, to the consternation of some, one of the editors of this special issue on the "Chemical Physics of Protein Folding," was quoted as saying, "What was called the protein folding problem 20 years ago is solved" (1). One purpose of this special issue is to drive home this point. The other, more important purpose is to illustrate how workers on the protein folding problem, by moving beyond their early obsession with seeming paradoxes (2), are developing a quantitative understanding of how the simpler biological structures assemble both in vitro and in vivo. The emerging quantitative understanding reveals simultaneously the richness of folding phenomena and the elegant simplicity of the underlying principles of spontaneous bio-molecular assembly.
机译：在2008年，一本名为《蛋白质折叠的化学物理》的特刊的编辑之一被引述说：“解决了20年前所谓的蛋白质折叠问题”（1）。本期特刊的目的之一就是要阐明这一点。另一个更重要的目的是说明蛋白质折叠问题的工作人员如何摆脱早期对表面矛盾的痴迷（2），从而对更简单的生物结构在体外和体内的组装方式有了定量的了解。新兴的定量理解同时揭示了折叠现象的丰富性和自发生物分子组装的基本原理的优雅简洁性。

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    Peter G. Wolynes; William A. Eaton; Alan R. Fersht;

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    Department of Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, TX 77005;

    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 OQH, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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