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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Antibodies for SV40 virus elevated in malignant pleural mesothelioma patients
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Antibodies for SV40 virus elevated in malignant pleural mesothelioma patients

机译:恶性胸膜间皮瘤患者SV40病毒抗体升高

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摘要

Though considered a rare form of cancer, recent studies have indicated that a quarter million people will die from human malignant pleural mesothelioma (MPM) in Europe during the next 3 decades. Although the mineral asbestos is widely thought to be the main causative agent of this neoplasm, infection by the DNA tumor virus simian virus 40 (SV40) has also been implicated. Elisa Mazzoni et al. (pp. 18066-18071) examined serum samples from patients affected by MPM and found the presence of antibodies that specifically react with two different SV40 mimotopes. Serum samples from 97 MPM-affected patients, the authors report, contained a statistically significant higher loading of antibodies against SV40 compared with a control group of healthy subjects with the same median age and gender.
机译:尽管被认为是一种罕见的癌症,但最近的研究表明,在未来的30年中,欧洲将有25万人死于人类恶性胸膜间皮瘤(MPM)。尽管广泛认为矿物石棉是该肿瘤的主要病原体,但也涉及DNA肿瘤病毒猿猴病毒40(SV40)的感染。 Elisa Mazzoni等。 (pp。18066-18071)检查了受MPM影响的患者的血清样品,发现存在与两种不同的SV40模拟表位特异性反应的抗体。作者报告说,与具有相同中位年龄和性别的健康受试者的对照组相比,来自97名受MPM影响的患者的血清样本在统计学上具有较高的抗SV40抗体载量。

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