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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes
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IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

机译：IL-10-诱导的microRNA-187负调节TLR4刺激的单核细胞中TNF-α，IL-6和IL-12p40的产生

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摘要

The proper development of the inflammatory response aimed at clearing infections while avoiding tissue damage and autoimmunity requires tight control by both positive and negative regulatory mechanisms. IL-10 negatively regulates acute and chronic inflammation by blocking or reducing the output from immune cells of proinflammatory cytokines, including TNF-α, IL-6, and IL-12 (1). Because the amplitude and duration of the inflammatory response are regulated precisely by IL-10, we were interested in determining its species-specific cellular and molecular targets. IL-10 suppresses cytokines primarily at the level of gene transcription but also influences post-transcriptional events (2). MicroRNAs (miRNAs) tune the inflammatory response (2, 3) by negatively regulating mRNA processing, stability, and translation of several genes that encode cytokines and chemokines produced by immune cells (3). However, it is un-
机译：旨在清除感染同时避免组织损伤和自身免疫的炎症反应的适当发展，需要通过积极和消极的调节机制进行严格控制。 IL-10通过阻断或减少促炎性细胞因子（包括TNF-α，IL-6和IL-12）的免疫细胞输出来负调控急性和慢性炎症（1）。由于炎症反应的幅度和持续时间受IL-10精确调节，因此我们对确定其物种特异性细胞和分子靶标感兴趣。 IL-10主要在基因转录水平上抑制细胞因子，但也影响转录后事件（2）。 MicroRNA（miRNA）通过负调节mRNA的表达，稳定性以及编码免疫细胞产生的细胞因子和趋化因子的几种基因的翻译来调节炎症反应（2、3）（3）。但是，这不是

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    Marzia Rossato; Graziella Curtale; Nicola Tamassia; Monica Castellucci; Laura Mori; Sara Gasperini; Barbara Mariotti; Mariacristina De Luca; Massimiliano Mirolo; Marco A. Cassatella; Massimo Locati; Flavia Bazzoni;

  • 作者单位

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

    Department of Medical Biotechnologies and Translational Medicine, University of Milan, 20089 Rozzano (Milan), Italy,Humanitas Clinical and Research Center, 20089 Rozzano (Milan), Italy;

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

    Department of Medical Biotechnologies and Translational Medicine, University of Milan, 20089 Rozzano (Milan), Italy,Humanitas Clinical and Research Center, 20089 Rozzano (Milan), Italy;

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

    Department of Medical Biotechnologies and Translational Medicine, University of Milan, 20089 Rozzano (Milan), Italy,Humanitas Clinical and Research Center, 20089 Rozzano (Milan), Italy;

    Department of Medical Biotechnologies and Translational Medicine, University of Milan, 20089 Rozzano (Milan), Italy,Humanitas Clinical and Research Center, 20089 Rozzano (Milan), Italy;

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

    Department of Medical Biotechnologies and Translational Medicine, University of Milan, 20089 Rozzano (Milan), Italy,Humanitas Clinical and Research Center, 20089 Rozzano (Milan), Italy;

    Division of General Pathology, Department of Pathology and Diagnostics, University of Verona, 1-37134 Verona, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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