How DNA mismatch repair proteins find their targets

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >How DNA mismatch repair proteins find their targets

【24h】

How DNA mismatch repair proteins find their targets

机译：DNA错配修复蛋白如何找到目标

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Proteins have the ability to locate specific targets on DNA, but how they do so remains poorly understood. Jason Gorman et al. (pp. 18251-18252) used single-molecule microscopy to visualize the postreplicative mismatch repair (MMR) proteins MutSa and MutLa, which correct errors in DNA synthesis, as they search for their DNA targets. The researchers used total internal reflection fluorescence microscopy (TIR-FM) and nanofabricated DNA curtains-DNA strands anchored to a lipid bilayer-containing mismatches to observe as MutSa searched for DNA mismatches and MutLa found the mismatch-bound MutSa.

机译：蛋白质具有在DNA上定位特定靶标的能力，但是如何做到这一点仍知之甚少。 Jason Gorman等。（第18251-18252页）（第18251-18252页）使用单分子显微镜对复制后的错配修复（MMR）蛋白MutSa和MutLa进行可视化，以纠正DNA合成中的错误，因为它们正在寻找其DNA靶标。研究人员使用全内反射荧光显微镜（TIR-FM）和纳米制造的DNA幕布-锚定在含脂质双层的错配上的DNA链进行观察，以观察MutSa寻找DNA错配，而MutLa发现与错配结合的MutSa。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第45期|18236-18236|共1页
作者

展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. [J] . Martin SA, McCabe N, Mullarkey Cancer Cell . 2010,第3期

机译：DNA聚合酶是DNA错配修复蛋白MSH2或MLH1缺乏的癌症的潜在治疗靶标。
2. Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway [J] . Nabieh Ayoub, Samah W. Awwad Biology Open . 2015,第4期

机译：KDM4赖氨酸脱甲基酶的过表达破坏了DNA错配修复途径的完整性KDM4赖氨酸脱甲基酶的过表达破坏了DNA错配修复途径的完整性
3. Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins [J] . Kirkpatrick DT, Petes TD Nature . 1997,第6636期

机译：DNA环的修复涉及DNA错配和核苷酸切除修复蛋白
4. Limited Proteolysis and Oxidative Surface Mapping for Characterization of the DNA-Binding Domain of Mismatch Repair Protein Pms1 by Mass Spectrometry [C] . Allison N. Schorzman, Jenny M. Cutalo, Lars C. Pedersen, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：有限的蛋白水解和氧化表面映射，用于表征错配修复蛋白PMS1的DNA结合结构域通过质谱法
5. Roles for the Intrinsically Disordered Linker Arms of MLH Proteins in DNA Mismatch Repair [D] . Furman, Christopher Michael. 2021

机译：用于DNA错配修复中的MLH蛋白的本质上无序接头臂的角色
6. DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1 [O] . Sarah A. Martin, Nuala McCabe, Michelle Mullarkey, -1

机译：DNA聚合酶作为DNA不匹配修复蛋白MSH2或MLH1缺乏的癌症的潜在治疗靶标
7. DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1 [O] . Martin, Sarah A., McCabe, Nuala, Mullarkey, Michelle, 2010

机译：DNA聚合酶作为DNA不匹配修复蛋白MSH2或MLH1缺乏的癌症的潜在治疗靶标
8. Role of Cell Cycle Regulation and MLH1, A Key DNA Mismatch Repair Protein, In211 Adaptive Survival Responses. Final Report [R] . Boothman, D. A. 1999

机译：细胞周期调节和mLH1，关键DNa错配修复蛋白，In211适应性生存反应的作用。总结报告

How DNA mismatch repair proteins find their targets

摘要

著录项

相似文献

相关主题

期刊订阅