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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway
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Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway

机译：分泌的Vago通过激活Jak-STAT途径来限制库蚊蚊子细胞中的西尼罗河病毒感染

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摘要

Although West Nile virus (WNV) and other arthropod-borne viruses are a major public health problem, the mechanisms of antiviral immunity in mosquitoes are poorly understood. Dicer-2, responsible for the RNAi-mediated response through the C-terminal RNase-III domain, also contains an N-terminal DExD/H-box helicase domain similar to mammalian RIG-I/MDA5 which, in Drosophila, was found to be required for activation of an antiviral gene, Vago. Here we show that the Culex orthologue of Vago (CxVago) is up-regulated in response to WNV infection in a Dicer-2-dependent manner. Further, our data show that CxVago is a secreted peptide that restricts WNV infection by activation of the Jak-STAT pathway. Thus, Vago appears to function as an IFN-like antiviral cytokine in mosquitoes.
机译：尽管西尼罗河病毒（WNV）和其他节肢动物传播的病毒是主要的公共卫生问题，但对蚊子中抗病毒免疫机制的了解却很少。 Dicer-2负责通过C端RNase-III结构域进行RNAi介导的应答，它还包含一个N端DExD / H-box解旋酶结构域，类似于哺乳动物的RIG-I / MDA5，在果蝇中发现是激活抗病毒基因Vago所必需的。在这里，我们显示了以Dicer-2依赖的方式响应WNV感染，瓦格库克斯直交系（CxVago）被上调。此外，我们的数据表明CxVago是一种通过激活Jak-STAT途径来限制WNV感染的分泌肽。因此，Vago在蚊子中似乎起着IFN样抗病毒细胞因子的作用。

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  • 作者

    Prasad N. Paradkar; Lee Trinidad; Rhonda Voysey; Jean-Bernard Duchemin; Peter J. Walker;

  • 作者单位

    CSIRO Animal, Food and Health Sciences,Australian Animal Health Laboratory, Geelong, VIC 3220 Australia;

    CSIRO Animal, Food and Health Sciences,Australian Animal Health Laboratory, Geelong, VIC 3220 Australia;

    CSIRO Animal, Food and Health Sciences,Australian Animal Health Laboratory, Geelong, VIC 3220 Australia;

    CSIRO Ecosystem Sciences, Australian Animal Health Laboratory, Geelong, VIC 3220 Australia;

    CSIRO Animal, Food and Health Sciences,Australian Animal Health Laboratory, Geelong, VIC 3220 Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    innate immunity; insect cytokine;

    机译：先天免疫;昆虫细胞因子;

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