Randomness profoundly influences untreated HIV progression

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Randomness profoundly influences untreated HIV progression

机译：随机性深刻影响未经治疗的艾滋病毒进展

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Among untreated HIV-infected humans, viral load and the time required to progress to AIDS differ widely and unpredictably. For example, although some individuals with certain human leukocyte antigen alleles are more likely to control untreated HIV infections without treatment, most will develop high viral loads and progress rapidly to AIDS. Elizabeth Read et al. (pp. 19727-19732) use a computational study of host-pathogen interaction to demonstrate how stochastic effects can profoundly influence disease dynamics, even in cases where high viral loads and strong selective pressures are present.

机译：在未经治疗的艾滋病毒感染者中，病毒载量和发展为艾滋病所需的时间差异很大且无法预测。例如，尽管某些具有某些人类白细胞抗原等位基因的个体更容易控制未经治疗的HIV感染，但大多数人会产生高病毒载量并迅速发展为AIDS。伊丽莎白·雷德（Elizabeth Read）等人。（pp。19727-19732）使用宿主-病原体相互作用的计算研究来证明，即使在存在高病毒载量和强大选择压力的情况下，随机效应如何深刻影响疾病动态。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第48期|19511-19511|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. HIV replication capacity is an independent predictor of disease progression in persons with untreated chronic HIV infection. [J] . Goetz MB, Leduc R, Wyman JAIDS: Journal of acquired immune deficiency syndromes . 2010,第4期

机译：HIV复制能力是未经治疗的慢性HIV感染者疾病进展的独立预测因子。
2. Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1 infection. [J] . Mellors JW, Margolick JB, Phair JP, JAMA: the Journal of the American Medical Association . 2007,第21期

机译：在未经治疗的HIV-1感染中，HIV-1 RNA，CD4细胞计数和CD4细胞计数斜率对于发展为AIDS和死亡的预后价值。
3. CD4 Cell Count and HIV DNA Level Are Independent Predictors of Disease Progression after Primary HIV Type 1 Infection in Untreated Patients [J] . Cécile Goujard, Mojgan Bonarek, Laurence Meyer, Clinical Infectious Diseases . 2006,第5期

机译：CD4细胞计数和HIV DNA水平是未经治疗的原发性HIV 1型感染后疾病进展的独立预测因子
4. DEVELOPMENT OF A NUMERICAL TOOL FOR THE PREDICTION OFFRACTURE PROGRESSION AND THE EVALUATION OF RESIDUALSTRENGTH IN RANDOMLY PERFORATED STRUCTURES [C] . Ilya Dukhovny, Constantine Klein, Sharon Arbel, 45th Israel Annual Conference on Aerospace Sciences: Book of Abstracts . 2005

机译：预测破裂过程的数值工具的开发和随机穿孔结构的残余强度评估。
5. An investigation of human and viral genetic factors influencing HIV disease progression and response to treatment in the era of highly active antiretroviral therapy (HAART). [D] . Brumme, Zabrina Lesley. 2006

机译：在高效抗逆转录病毒疗法（HAART）时代，对影响HIV疾病进展和对治疗反应的人类和病毒遗传因素的调查。
6. Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial [O] . Christa Kasang, Samuel Kalluvya, Charles Majinge, 2011

机译：泼尼松龙对未经抗逆转录病毒治疗的HIV感染疾病进展的影响：一项为期2年的随机，双盲安慰剂对照临床试验
7. Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial [O] . Kasang, Christa, Kalluvya, Samuel, Majinge, Charles, 2017

机译：泼尼松龙对未经抗逆转录病毒治疗的HIV感染疾病进展的影响：一项为期2年的随机，双盲安慰剂对照临床试验

Randomness profoundly influences untreated HIV progression

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