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Mechanism for adaptive remodeling of the bacterial flagellar switch

机译：细菌鞭毛开关的自适应重塑机制

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摘要

The bacterial flagellar motor has been shown in previous work to adapt to changes in the steady-state concentration of the chemo-taxis signaling molecule, CheY-P, by changing the FliM content. We show here that the number of FliM molecules in the motor and the fraction of FliM molecules that exchange depend on the direction of flagellar rotation, not on CheY-P binding per se. Our results are consistent with a model in which the structural differences associated with the direction of rotation modulate the strength of FliM binding. When the motor spins counterclockwise, FliM binding strengthens, the fraction of FliM molecules that exchanges decreases, and the ring content increases. The larger number of CheY-P binding sites enhances the motor's sensitivity, i.e., the motor adapts. An interesting unresolved question is how additional copies of FliM might be accommodated.
机译：在以前的工作中已经表明，细菌鞭毛运动通过改变FliM含量来适应化学趋化信号分子CheY-P的稳态浓度变化。我们在这里显示出马达中FliM分子的数量和交换的FliM分子的比例取决于鞭毛旋转的方向，而不是CheY-P结合本身。我们的结果与一个模型一致，在该模型中，与旋转方向相关的结构差异调节了FliM结合的强度。当电动机逆时针旋转时，FliM结合增强，交换的FliM分子比例减少，环含量增加。大量的CheY-P结合位点可增强马达的灵敏度，即马达适应性强。一个有趣的未解决问题是如何容纳FliM的其他副本。

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