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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Biomimetic peptoid oligomers as dual-action antifreeze agents
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Biomimetic peptoid oligomers as dual-action antifreeze agents

机译:仿生拟肽低聚物作为双作用防冻剂

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摘要

The ability of natural peptides and proteins to influence the formation of inorganic crystalline materials has prompted the design of synthetic compounds for the regulation of crystal growth, including the freezing of water and growth of ice crystals. Despite their versatility and ease of structural modification, peptidomimetic oligomers have not yet been explored extensively as crystallization modulators. This report describes a library of synthetic A/-substituted glycine peptoid oligomers that possess "dual-action" antifreeze activity as exemplified by ice crystal growth inhibition concomitant with melting temperature reduction. We investigated the structural features responsible for these phenomena and observed that peptoid antifreeze activities depend both on oligomer backbone structure and side chain chemical composition. These studies reveal the capability of peptoids to act as ice crystallization regulators, enabling the discovery of a unique and diverse family of synthetic oligomers with potential as antifreeze agents in food production and biomedicine.
机译:天然肽和蛋白质影响无机晶体材料形成的能力促使设计用于调节晶体生长的合成化合物,包括水的冻结和冰晶的生长。尽管它们具有通用性并且易于结构修饰,但尚未广泛研究拟肽低聚物作为结晶调节剂。该报告描述了具有“双重作用”抗冻活性的合成的A /-取代的甘氨酸类肽低聚物的文库,例如通过抑制冰晶生长和降低熔融温度来举例说明。我们研究了造成这些现象的结构特征,并观察到类肽的抗冻活性取决于低聚物主链结构和侧链化学组成。这些研究揭示了类肽充当冰晶调节剂的能力,从而使人们发现了独特而多样的合成低聚物家族,它们在食品生产和生物医学中具有作为防冻剂的潜力。

著录项

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  • 作者单位

    Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003;

    Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003;

    Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003;

    Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003;

    Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003;

    Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    tailored additive; X-ray diffraction;

    机译:量身定制的添加剂;X射线衍射;

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