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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Acute ethanol responses in Drosophila are sexually dimorphic
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Acute ethanol responses in Drosophila are sexually dimorphic

机译：果蝇中的急性乙醇反应是性二态

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摘要

In mammalian and insect models of ethanol intoxication, low doses of ethanol stimulate locomotor activity whereas high doses induce sedation. Sex differences in acute ethanol responses, which occur in humans, have not been characterized in Drosophila. In this study, we find that male flies show increased ethanol hyperactivity and greater resistance to ethanol sedation compared with females. We show that the sex determination gene transformer (tra) acts in the developing nervous system, likely through regulation of fruitless (fru), to at least partially mediate the sexual dimorphism in ethanol sedation. Although pharmacokinetic differences may contribute to the increased sedation sensitivity of females, neuronal tra expression regulates ethanol sedation independently of ethanol pharmacokinetics. We also show that acute activation of fru-expressing neurons affects ethanol sedation, further supporting a role for fru in regulating this behavior. Thus, we' have characterized previously undescribed sex differences in behavioral responses to ethanol, and implicated fru in mediating a subset of these differences.
机译：在乙醇中毒的哺乳动物和昆虫模型中，低剂量的乙醇刺激运动活性，而高剂量的乙醇引起镇静作用。在果蝇中尚未发现人类发生的急性乙醇反应的性别差异。在这项研究中，我们发现雄蝇比雌蝇表现出更高的乙醇活性和对乙醇镇静的抵抗力。我们显示性别决定基因转换器（tra）在发展中的神经系统中起作用，可能通过无果（fru）的调节来至少部分介导乙醇镇静中的性二态性。尽管药代动力学差异可能有助于提高女性的镇静敏感性，但神经元tra表达独立于乙醇药代动力学而调节乙醇镇静作用。我们还显示，表达果糖的神经元的急性激活影响乙醇镇静作用，进一步支持果糖在调节这种行为中的作用。因此，我们已经表征了乙醇行为反应中先前未描述的性别差异，并暗示了介导这些差异的子集。

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    Anita V. Devineni; Ulrike Heberlein;

  • 作者单位

    Program in Neuroscience and Department of Anatomy, University of California, San Francisco, CA 94158,Department of Neuroscience, Columbia University, New York, NY 10032;

    Program in Neuroscience and Department of Anatomy, University of California, San Francisco, CA 94158,Howard Hughes Medical Institute, Janelia Farm Research Campus, Ash- burn, VA 20147;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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