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Converging on a mechanism for choline degradation

机译：汇聚胆碱降解机制

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摘要

In PNAS, Craciun and Balskus (1) combine biochemical intuition with modern genome mining techniques to discover the elusive enzyme responsible for catalyzing the degradation of choline (1, Scheme 1). Choline is an essential nutrient in higher organisms that is required for the biosynthesis of the neu-rotransmitter acetylcholine and the head group of several phospholipids, and that serves as a source of the methyl groups for methionine and S-adenosylmethionine (2). In humans and other mammals, choline is catabolized to trimethylamine (TMA; 2, Scheme 1) by symbiotic gut microbes, and irregularities in choline and TMA metabolism have been linked to liver and cardiovascular diseases, atherosclerosis, and deficiencies in fetal brain development (3-5). TMA derived from choline is also a substrate for methanogenesis by marine microorganisms and, as such, contributes to global production of the greenhouse gas methane.
机译：在PNAS中，Craciun和Balskus（1）将生化直觉与现代基因组挖掘技术结合起来，发现了负责催化胆碱降解的难以捉摸的酶（方案1，方案1）。胆碱是高等生物中必需的营养素，它是生物合成神经递质乙酰胆碱和几种磷脂的头基所必需的，并且是蛋氨酸和S-腺苷蛋氨酸的甲基来源（2）。在人类和其他哺乳动物中，胆碱被共生肠道微生物分解代谢为三甲胺（TMA; 2，方案1），胆碱和TMA代谢异常与肝和心血管疾病，动脉粥样硬化和胎儿脑发育不足有关（3 -5）。源自胆碱的TMA还是海洋微生物甲烷化的底物，因此有助于全球生产温室气体甲烷。

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    Christopher J. Thibodeaux; Wilfred A. van der Donk;

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    Institute for Genomic Biology University of Illinois,Urbana, IL 61801;

    Institute for Genomic Biology University of Illinois,Urbana, IL 61801,Howard Hughes Medical Institute University of Illinois,Urbana, IL 61801,Department of Chemistry, University of Illinois,Urbana, IL 61801;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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