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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans
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Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans

机译:秀丽隐杆线虫引起的二氧化碳感觉需要受体型鸟苷酸环化酶

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摘要

CO_2 is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO_2 avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO_2 specifically activates the BAG neurons and that the CO_2-sensing function of BAG neurons requires TAX-2/ TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO_2 sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO_2.
机译:CO_2既是动物生理的重要调节剂,也是许多动物进行宿主检测,食物定位和寻找伴侣的重要感觉线索。自由活动的土壤线虫秀丽隐杆线虫显示出CO_2回避行为,这需要一对纤毛的感觉神经元,即BAG神经元。使用体内钙成像,我们显示CO_2特异性激活BAG神经元,并且BAG神经元的CO_2感应功能需要TAX-2 / TAX-4环状核苷酸门控离子通道和受体型鸟苷酸环化酶GCY-9。我们的研究结果描绘了CO_2感应的分子途径,并表明受体型鸟苷酸环化酶的激活是动物检测环境CO_2的进化保守机制。

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  • 作者单位

    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125;

    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232;

    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232;

    Friedrich Miescher Laboratory of the Max Planck Society, 72076 Tubingen, Germany,Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany;

    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany;

    Friedrich Miescher Laboratory of the Max Planck Society, 72076 Tubingen, Germany;

    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232;

    Howard Hughes Medical Institute,Department of Biology and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125;

    Howard Hughes Medical Institute,Department of Biology and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139,Department of Cell Biology and the Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York NY 10016;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    guanylyl cyclase; olfaction; transcriptional profiling; regulator of G protein signaling; chemosensation;

    机译:鸟苷酸环化酶;嗅觉;转录谱;G蛋白信号传导调节剂;化学传感;

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