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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations
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Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations

机译:固定化疏水性聚阳离子使流感病毒失活的机理

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摘要

N,N-Dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.
机译:我们已经证明,在固体表面上涂有N,N-十二烷基,甲基-聚乙烯亚胺涂层可以对流感病毒的水溶液进行消毒。在这里,我们阐明这种现象的机理。基于感染性,蛋白质,RNA和扫描电子显微镜的实验表明,与疏水性聚阳离子涂层接触后,流感病毒(包括致病性人和禽,既是野生型又是耐药性的菌株)不可逆地粘附它,随后是结构破坏和失活;随后,病毒RNA释放到溶液中,而蛋白质保持吸附状态。

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  • 作者单位

    Departments of Chemistry,Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Chemical Engineering,Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Chemical Engineering,Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139,Departments of Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Chemistry,Massachusetts Institute of Technology, Cambridge, MA 02139,Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antiviral; biocide; virucidal coating;

    机译:抗病毒;杀菌剂;抗病毒涂层;

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