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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles
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Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

机译:利用红细胞的机械生物学模拟来延长水凝胶微粒的循环时间

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摘要

It has long been hypothesized that elastic modulus governs the biodistribution and circulation times of particles and cells in blood; however, this notion has never been rigorously tested. We synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red blood cells in size and shape, and tested their behavior in vivo. Decreasing the modulus of these particles altered their biodistribution properties, allowing them to bypass several organs, such as the lung, that entrapped their more rigid counterparts, resulting in increasingly longer circulation times well past those of conventional microparticles. An 8-fold decrease in hydrogel modulus correlated to a greater than 30-fold increase in the elimination phase half-life for these particles. These results demonstrate a critical design parameter for hydrogel microparticles.
机译:长期以来,人们一直认为弹性模量决定着血液中颗粒和细胞的生物分布和循环时间。但是,这一概念从未经过严格的检验。我们合成了在生理范围内具有可调弹性的水凝胶微粒,其大小和形状类似于红细胞,并在体内测试了它们的行为。降低这些颗粒的模量会改变它们的生物分布特性,从而使它们绕过包裹更坚硬的对应部分的多个器官(如肺),导致循环时间越来越长,远远超过了传统的微粒。水凝胶模量降低8倍,与这些颗粒的消除相半衰期增加30倍以上有关。这些结果证明了水凝胶微粒的关键设计参数。

著录项

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  • 作者单位

    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Physics,University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Institute for Nanomedicine, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Institute for Nanomedicine, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Eschelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Eschelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,lnstitute for Pharmacogenomics and Individualized Therapy,University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry,Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599;

    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Lineberger Comprehensive Cancer Center,University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Institute for Nanomedicine, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Eschelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599,Department of Chemistry,Institute for Advanced Materials, University of North Carolina, Chapel Hill, NC 27599,Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695,Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomimetic; deformability; drug carriers; long circulating; red blood cell mimic;

    机译:仿生;变形能力毒品携带者;长期流通;红细胞模拟;

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