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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Kruppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression
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Kruppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression

机译：Kruppel样因子2（KLF2）调节B细胞反应性，亚群分化和运输分子表达

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摘要

The transcription factor Kruppel-like factor 2 (KLF2) is critical for normal trafficking of T lymphocytes, but its role in B cells is unclear. We report that B cell-specific KLF2 deficiency leads to decreased expression of the trafficking molecules CD62L and β7-integrin, yet expression of sphingosine-1 phosphate receptor 1 (which is a critical target of KLF2 in T cells) was, unexpectedly, minimally altered. Unexpectedly, Klf2 deletion led to a drastic reduction in the B1 B-cell pool and a substantial increase in transitional and marginal zone B-cell numbers. In addition, we observed that KLF2-deficient B cells showed increased apoptosis and impaired proliferation after B-cell receptor cross-linking. Gene expression analysis indicated that KLF2-deficient follicular B cells display numerous characteristics shared by normal marginal zone B cells, including reduced expression of several signaling molecules that may contribute to defective activation of these cells. Hence, our data indicate that KLF2 plays a critical role in dictating normal subset differentiation and functional reactivity of mature B cells.
机译：转录因子Kruppel样因子2（KLF2）对于T淋巴细胞的正常运输至关重要，但尚不清楚其在B细胞中的作用。我们报告说，B细胞特异性KLF2缺乏症导致贩运分子CD62L和β7-整联蛋白的表达降低，而鞘氨醇-1磷酸受体1（这是T细胞中KLF2的关键靶点）的表达出乎意料地被最小程度地改变。出乎意料的是，Klf2缺失导致B1 B细胞池的急剧减少，以及过渡和边缘区B细胞数量的大幅增加。此外，我们观察到缺乏KLF2的B细胞在B细胞受体交联后显示出增加的凋亡和受损的增殖。基因表达分析表明，缺乏KLF2的卵泡B细胞显示出正常边缘B区细胞共有的许多特征，包括几种信号分子的表达降低，这可能有助于这些细胞的活化缺陷。因此，我们的数据表明KLF2在决定成熟B细胞的正常子集分化和功能反应性中起关键作用。

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    Geoffrey T. Hart; Xiaodan Wang; Kristin A. Hogquist; Stephen C. Jameson;

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    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55414;

    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55414;

    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55414;

    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55414;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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