...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells
【24h】

Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells

机译：维生素A依赖的活化T细胞c1（NFATc1）核因子的转录激活对于B1细胞的发育和存活至关重要

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

B1 cells represent a distinct subset of B cells that produce most of the natural serum IgM and much of the gut IgA and function as an important component of early immune responses to pathogens. The development of B1 cells depends on the nuclear factor of activated T cells c1 (NFATc1), a transcription factor abundantly expressed by B1 cells but not by conventional B2 cells. However, the factors that regulate the expression of NFATc1 in B1 cells remain unknown. Here we show that a vitamin A-deficient diet results in reduction of NFATc1 expression in B1 cells and almost complete loss of the B1 cell compartment. As a consequence, vitamin A-deficient mice have reduced serum IgM and are unable to mount T cell-independent antibody responses against bacterial antigens. We demonstrate that injection of all-trans retinoic acid induces the expression of NFATc1, particularly from the constitutive P2 promoter, and leads to the increase of the B1 cells. Thus, the retinoic acid-dependent pathway is critical for regulating NFATc1 expression and for maintenance of the natural memory B cell compartment.
机译：B1细胞代表B细胞的一个独特子集，该B细胞产生大多数天然血清IgM和大部分肠道IgA，并作为对病原体的早期免疫反应的重要组成部分。 B1细胞的发育取决于活化的T细胞c1（NFATc1）的核因子，该因子是B1细胞大量表达的转录因子，而不是常规B2细胞大量表达的转录因子。但是，调节B1细胞中NFATc1表达的因素仍然未知。在这里，我们表明缺乏维生素A的饮食会导致B1细胞中NFATc1表达的减少，并使B1细胞区室几乎完全丧失。结果，缺乏维生素A的小鼠的血清IgM降低，并且无法引发针对细菌抗原的非T细胞依赖性抗体应答。我们证明注射全反式维甲酸诱导NFATc1的表达，特别是从组成型P2启动子表达，并导致B1细胞的增加。因此，视黄酸依赖性途径对于调节NFATc1表达和维持自然记忆B细胞区室至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号