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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus
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Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus

机译：疫苗接种可诱导针对多种亚型流感病毒的广泛而完善的交叉保护

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摘要

Development of an influenza vaccine that provides broadly cross-protective immunity has been a scientific challenge for more than half a century. This study presents an approach to overcome strain-specific protection by supplementing conventional vaccines with virus-like particles (VLPs) containing the conserved M2 protein (M2 VLPs) in the absence of adjuvants. We demonstrate that an inactivated influenza vaccine supplemented with M2 VLPs prevents disease symptoms without showing weight loss and confers complete cross protection against lethal challenge with heterolo-gous influenza A viruses including the 2009 H1N1 pandemic virus as well as heterosubtypic H3N2 and H5N1 influenza viruses. Cross-protective immunity was long-lived, for more than 7 mo. Immune sera from mice immunized with M2 VLP supplemented vaccine transferred cross protection to naive mice. Dendritic and macro-phage cells were found to be important for this cross protection mediated by immune sera. The results provide evidence that supplementation of seasonal influenza vaccines with M2 VLPs is a promising approach for overcoming the limitation of strain-specific protection by current vaccines and developing a universal influenza A vaccine.
机译：半个世纪以来，开发一种具有广泛交叉保护作用的流感疫苗一直是一项科学挑战。这项研究提出了一种在没有佐剂的情况下通过向常规疫苗中添加包含保守M2蛋白（M2 VLP）的病毒样颗粒（VLP）来克服菌株特异性保护的方法。我们证明，补充有M2 VLP的灭活流感疫苗可预防疾病症状而不显示体重减轻，并赋予针对包括2009 H1N1大流行性病毒以及H3N2和H5N1异型流感病毒在内的A型杂合甲型流感病毒致命性攻击的完整交叉保护。交叉保护免疫的寿命超过7个月。用补充M2 VLP的疫苗免疫的小鼠的免疫血清将交叉保护转移给了幼稚小鼠。发现树突状细胞和巨噬细胞对免疫血清介导的这种交叉保护很重要。结果提供了证据，证明季节性疫苗补充M2 VLP是克服当前疫苗对菌株特异性保护的局限性并开发通用的A型流感疫苗的有前途的方法。

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