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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Meiotic, cryptic, and stable unannotated transcripts: Noncoding RNAs add to the epigenetic tool box controlling meiotic development
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Meiotic, cryptic, and stable unannotated transcripts: Noncoding RNAs add to the epigenetic tool box controlling meiotic development

机译：减数分裂，隐秘且稳定的无注释转录物：非编码RNA添加到控制减数分裂发育的表观遗传工具箱中

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摘要

Less than 2% of the genome codes for the ≈20,000 genes found in humans. Rather than representing a genetic desert as originally thought, high-resolution expression profiling has found that these noncoding regions of the chromosome are actively transcribed, producing several types of noncoding RNAs (ncRNAs). Recent studies have found that these ncRNAs can be divided into several groups based on origin and/or function (1). For example, small ncRNAs (e.g., small interfering RNAs or microRNAs) negatively regulate gene expression by targeting specific mRNAs for destruction or preventing their translation.
机译：不到2％的基因组编码了在人类中发现的大约20,000个基因。高分辨率表达谱分析并未像最初认为的那样代表遗传荒漠，而是发现染色体的这些非编码区被主动转录，从而产生几种类型的非编码RNA（ncRNA）。最近的研究发现，这些ncRNA可以根据来源和/或功能分为几类（1）。例如，小的ncRNA（例如，小的干扰RNA或microRNA）通过靶向特定的mRNA来破坏或阻止其翻译，从而负面调节基因的表达。

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